CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(seed) - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(seed) & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(seed) PPfold(seed)
MCC 0.254 > 0.214
Average MCC ± 95% Confidence Intervals 0.090 ± 0.139 < 0.112 ± 0.124
Sensitivity 0.065 < 0.074
Positive Predictive Value 1.000 > 0.634
Total TP 23 < 26
Total TN 30501 > 30483
Total FP 0 < 80
Total FP CONTRA 0 < 1
Total FP INCONS 0 < 14
Total FP COMP 0 < 65
Total FN 330 > 327
P-value 1.15369476696e-07

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Performance plots


  1. Comparison of performance of Carnac(seed) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(seed) and PPfold(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(seed) and PPfold(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(seed) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(seed) and PPfold(seed)).

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Performance of Carnac(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 23
Total TN 30501
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 330
Total Scores
MCC 0.254
Average MCC ± 95% Confidence Intervals 0.090 ± 0.139
Sensitivity 0.065
Positive Predictive Value 1.000
Nr of predictions 15

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.22 1.00 4 524 0 0 0 0 14
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W1K_J 0.00 0.00 0.00 0 1678 0 0 0 0 31
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24
4FRN_A 0.00 0.00 0.00 0 1848 0 0 0 0 28
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 26
Total TN 30483
Total FP 80
Total FP CONTRA 1
Total FP INCONS 14
Total FP COMP 65
Total FN 327
Total Scores
MCC 0.214
Average MCC ± 95% Confidence Intervals 0.112 ± 0.124
Sensitivity 0.074
Positive Predictive Value 0.634
Nr of predictions 15

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.49 0.33 0.75 6 520 2 0 2 0 12
3J3E_8 0.00 0.00 0.00 0 2742 6 0 0 6 15
3J3F_8 0.19 0.11 0.33 2 4755 24 0 4 20 17
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W1K_J 0.00 0.00 0.00 0 1678 0 0 0 0 31
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
3ZEX_C 0.15 0.07 0.33 2 5368 24 0 4 20 27
4A1C_2 0.10 0.05 0.20 1 4511 23 0 4 19 19
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24
4FRN_A 0.00 0.00 0.00 0 1848 0 0 0 0 28
4JF2_A 0.76 0.63 0.94 15 1066 1 1 0 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.