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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) Multilign(seed)
MCC 0.706 > 0.625
Average MCC ± 95% Confidence Intervals 0.609 ± 0.482 > 0.598 ± 0.338
Sensitivity 0.571 < 0.587
Positive Predictive Value 0.878 > 0.673
Total TP 72 < 74
Total TN 11870 > 11842
Total FP 14 < 38
Total FP CONTRA 2 < 16
Total FP INCONS 8 < 20
Total FP COMP 4 > 2
Total FN 54 > 52
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 72
Total TN 11870
Total FP 14
Total FP CONTRA 2
Total FP INCONS 8
Total FP COMP 4
Total FN 54
Total Scores
MCC 0.706
Average MCC ± 95% Confidence Intervals 0.609 ± 0.482
Sensitivity 0.571
Positive Predictive Value 0.878
Nr of predictions 5

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.00 0.00 0.00 0 2738 4 1 3 0 15
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.85 0.76 0.96 22 1510 1 0 1 0 7
3ZEX_C 0.44 0.31 0.64 9 5360 7 1 4 2 20
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 74
Total TN 11842
Total FP 38
Total FP CONTRA 16
Total FP INCONS 20
Total FP COMP 2
Total FN 52
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.598 ± 0.338
Sensitivity 0.587
Positive Predictive Value 0.673
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.19 0.20 0.19 3 2726 13 8 5 0 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3ZEX_C 0.50 0.45 0.57 13 5351 11 3 7 1 16
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.