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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

  4. Performance of CRWrnafold - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(seed) & CRWrnafold [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(seed) CRWrnafold
MCC 0.727 > 0.513
Average MCC ± 95% Confidence Intervals 0.631 ± 0.342 > 0.533 ± 0.387
Sensitivity 0.548 > 0.524
Positive Predictive Value 0.972 > 0.516
Total TP 69 > 66
Total TN 8911 > 8854
Total FP 6 < 83
Total FP CONTRA 1 < 21
Total FP INCONS 1 < 41
Total FP COMP 4 < 21
Total FN 57 < 60
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(seed) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and CRWrnafold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and CRWrnafold).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP 69
Total TN 8911
Total FP 6
Total FP CONTRA 1
Total FP INCONS 1
Total FP COMP 4
Total FN 57
Total Scores
MCC 0.727
Average MCC ± 95% Confidence Intervals 0.631 ± 0.342
Sensitivity 0.548
Positive Predictive Value 0.972
Nr of predictions 6

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.00 0.00 0.00 0 528 0 0 0 0 18
3SD1_A 0.85 0.76 0.96 22 1510 1 0 1 0 7
4A1C_2 0.60 0.40 0.89 8 4507 3 1 0 2 12
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.72 0.53 1.00 8 464 0 0 0 0 7
4ENC_A 0.73 0.53 1.00 8 488 0 0 0 0 7

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 66
Total TN 8854
Total FP 83
Total FP CONTRA 21
Total FP INCONS 41
Total FP COMP 21
Total FN 60
Total Scores
MCC 0.513
Average MCC ± 95% Confidence Intervals 0.533 ± 0.387
Sensitivity 0.524
Positive Predictive Value 0.516
Nr of predictions 6

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3SD1_A 0.63 0.66 0.61 19 1502 12 6 6 0 10
4A1C_2 0.19 0.25 0.15 5 4483 44 8 20 16 15
4AOB_A 0.71 0.69 0.74 20 1410 8 4 3 1 9
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.85 0.73 1.00 11 485 2 0 0 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.