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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric ContextFold CMfinder(20)
MCC 0.585 > 0.580
Average MCC ± 95% Confidence Intervals 0.572 ± 0.485 > 0.564 ± 0.352
Sensitivity 0.612 > 0.500
Positive Predictive Value 0.566 < 0.681
Total TP 60 > 49
Total TN 10786 < 10820
Total FP 70 > 26
Total FP CONTRA 27 > 12
Total FP INCONS 19 > 11
Total FP COMP 24 > 3
Total FN 38 < 49
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and CMfinder(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and CMfinder(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 60
Total TN 10786
Total FP 70
Total FP CONTRA 27
Total FP INCONS 19
Total FP COMP 24
Total FN 38
Total Scores
MCC 0.585
Average MCC ± 95% Confidence Intervals 0.572 ± 0.485
Sensitivity 0.612
Positive Predictive Value 0.566
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J3D_C 0.79 0.79 0.79 15 949 4 3 1 0 4
3J3E_8 -0.01 0.00 0.00 0 2722 29 12 8 9 15
3J3F_8 0.36 0.42 0.31 8 4735 32 9 9 14 11
4FRG_B 0.77 0.71 0.85 17 1182 3 2 1 0 7

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 49
Total TN 10820
Total FP 26
Total FP CONTRA 12
Total FP INCONS 11
Total FP COMP 3
Total FN 49
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352
Sensitivity 0.500
Positive Predictive Value 0.681
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.