CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	Contrafold		NanoFolder
MCC	0.552	>	0.406
Average MCC ± 95% Confidence Intervals	0.522 ± 0.190	>	0.450 ± 0.163
Sensitivity	0.572	>	0.516
Positive Predictive Value	0.544	>	0.333
Total TP	143	>	129
Total TN	20918	>	20794
Total FP	170	<	311
Total FP CONTRA	36	<	98
Total FP INCONS	84	<	160
Total FP COMP	50	<	53
Total FN	107	<	121
P-value	2.66715895098e-08

Comparison of performance of Contrafold and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and NanoFolder).

Total Scores
MCC	0.552
Average MCC ± 95% Confidence Intervals	0.522 ± 0.190
Sensitivity	0.572
Positive Predictive Value	0.544
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	0.46	0.39	0.58	7	516	5	3	2	0	11
2M58_A	-	-0.02	0.00	0.00	0	531	13	0	13	0	12
3J3D_C	tRNA links to Rfam database...	0.71	0.79	0.65	15	945	8	3	5	0	4
3J3E_8	5_8S_rRNA links to Rfam database...	0.12	0.13	0.11	2	2724	32	5	11	16	13
3J3F_8	5_8S_rRNA links to Rfam database...	0.35	0.47	0.26	9	4726	44	13	13	18	10
3U4M_B	-	0.81	0.77	0.85	17	1256	5	0	3	2	5
3W3S_B	tRNA-Sec links to Rfam database...	0.98	0.97	1.00	32	1957	1	0	0	1	1
4A1C_2	5_8S_rRNA links to Rfam database...	0.21	0.25	0.19	5	4489	33	9	13	11	15
4AOB_A	SAM links to Rfam database...	0.53	0.52	0.56	15	1410	13	3	9	1	14
4ATO_G	-	0.52	0.57	0.50	4	212	4	0	4	0	3
4ENC_A	crcB links to Rfam database...	0.85	0.73	1.00	11	485	1	0	0	1	4
4JF2_A	preQ1-II links to Rfam database...	0.89	0.79	1.00	19	1063	0	0	0	0	5
4JRC_A	-	0.38	0.41	0.39	7	604	11	0	11	0	10

Total Scores
MCC	0.406
Average MCC ± 95% Confidence Intervals	0.450 ± 0.163
Sensitivity	0.516
Positive Predictive Value	0.333
Nr of predictions	13

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	0.54	0.61	0.50	11	506	11	1	10	0	7
2M58_A	-	0.45	0.58	0.37	7	525	13	6	6	1	5
3J3D_C	tRNA links to Rfam database...	0.76	0.95	0.62	18	939	11	9	2	0	1
3J3E_8	5_8S_rRNA links to Rfam database...	-0.01	0.00	0.00	0	2707	47	11	24	12	15
3J3F_8	5_8S_rRNA links to Rfam database...	0.30	0.47	0.19	9	4714	57	21	17	19	10
3U4M_B	-	0.77	0.91	0.67	20	1246	12	6	4	2	2
3W3S_B	tRNA-Sec links to Rfam database...	0.18	0.21	0.18	7	1949	34	2	31	1	26
4A1C_2	5_8S_rRNA links to Rfam database...	-0.01	0.00	0.00	0	4469	61	18	29	14	20
4AOB_A	SAM links to Rfam database...	0.39	0.41	0.39	12	1406	20	4	15	1	17
4ATO_G	-	0.72	1.00	0.54	7	207	6	6	0	0	0
4ENC_A	crcB links to Rfam database...	0.66	0.73	0.61	11	478	9	2	5	2	4
4JF2_A	preQ1-II links to Rfam database...	0.55	0.67	0.47	16	1048	19	9	9	1	8
4JRC_A	-	0.56	0.65	0.50	11	600	11	3	8	0	6

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.