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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric Cylofold CMfinder(20)
MCC 0.838 > 0.696
Average MCC ± 95% Confidence Intervals 0.837 ± 1.235 > 0.690 ± 1.958
Sensitivity 0.822 > 0.511
Positive Predictive Value 0.860 < 0.958
Total TP 37 > 23
Total TN 2378 < 2397
Total FP 7 > 2
Total FP CONTRA 3 > 1
Total FP INCONS 3 > 0
Total FP COMP 1 = 1
Total FN 8 < 22
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and CMfinder(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and CMfinder(20)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 37
Total TN 2378
Total FP 7
Total FP CONTRA 3
Total FP INCONS 3
Total FP COMP 1
Total FN 8
Total Scores
MCC 0.838
Average MCC ± 95% Confidence Intervals 0.837 ± 1.235
Sensitivity 0.822
Positive Predictive Value 0.860
Nr of predictions 2

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.74 0.76 0.73 16 1197 7 3 3 1 5
4FRG_B 0.93 0.88 1.00 21 1181 0 0 0 0 3

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 23
Total TN 2397
Total FP 2
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 1
Total FN 22
Total Scores
MCC 0.696
Average MCC ± 95% Confidence Intervals 0.690 ± 1.958
Sensitivity 0.511
Positive Predictive Value 0.958
Nr of predictions 2

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.