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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Murlet(seed)
MCC 0.668 > 0.534
Average MCC ± 95% Confidence Intervals 0.612 ± 0.105 > 0.529 ± 0.077
Sensitivity 0.611 > 0.349
Positive Predictive Value 0.738 < 0.828
Total TP 347 > 198
Total TN 46742 < 46973
Total FP 200 > 50
Total FP CONTRA 45 > 6
Total FP INCONS 78 > 35
Total FP COMP 77 > 9
Total FN 221 < 370
P-value 5.10776592382e-08

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(seed)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 347
Total TN 46742
Total FP 200
Total FP CONTRA 45
Total FP INCONS 78
Total FP COMP 77
Total FN 221
Total Scores
MCC 0.668
Average MCC ± 95% Confidence Intervals 0.612 ± 0.105
Sensitivity 0.611
Positive Predictive Value 0.738
Nr of predictions 22

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 518 12 0 10 2 18
3A3A_A 0.84 0.77 0.92 23 1475 4 0 2 2 7
3GX2_A 0.83 0.82 0.85 23 1422 7 2 2 3 5
3IVN_B 0.69 0.57 0.87 13 888 2 2 0 0 10
3J3E_8 0.23 0.20 0.27 3 2731 14 3 5 6 12
3J3F_8 0.48 0.47 0.50 9 4743 21 5 4 12 10
3LA5_A 0.82 0.72 0.95 18 935 1 1 0 0 7
3NPB_A 0.76 0.70 0.84 26 2247 10 2 3 5 11
3O58_3 0.54 0.50 0.58 11 4745 20 5 3 12 11
3PDR_A 0.87 0.88 0.86 44 4789 10 4 3 3 6
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.74 0.76 0.73 22 1503 9 4 4 1 7
3W1K_J 0.92 0.90 0.93 28 1648 3 1 1 1 3
3W3S_B 0.74 0.70 0.79 23 1960 7 0 6 1 10
3ZEX_C 0.39 0.31 0.50 9 5356 21 3 6 12 20
4A1C_2 0.45 0.40 0.50 8 4500 20 4 4 12 12
4AOB_A 0.71 0.69 0.74 20 1410 10 2 5 3 9
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.48 0.40 0.60 6 486 4 1 3 0 9
4FRG_B 0.49 0.42 0.59 10 1185 8 2 5 1 14
4FRN_A 0.70 0.68 0.73 19 1822 7 3 4 0 9
4JF2_A 0.41 0.33 0.53 8 1067 8 1 6 1 16

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 198
Total TN 46973
Total FP 50
Total FP CONTRA 6
Total FP INCONS 35
Total FP COMP 9
Total FN 370
Total Scores
MCC 0.534
Average MCC ± 95% Confidence Intervals 0.529 ± 0.077
Sensitivity 0.349
Positive Predictive Value 0.828
Nr of predictions 22

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 0 12 0 18
3A3A_A 0.63 0.40 1.00 12 1488 0 0 0 0 18
3GX2_A 0.70 0.50 1.00 14 1435 1 0 0 1 14
3IVN_B 0.62 0.52 0.75 12 887 4 2 2 0 11
3J3E_8 0.36 0.13 1.00 2 2740 2 0 0 2 13
3J3F_8 0.61 0.37 1.00 7 4754 0 0 0 0 12
3LA5_A 0.67 0.56 0.82 14 937 3 1 2 0 11
3NPB_A 0.59 0.35 1.00 13 2265 2 0 0 2 24
3O58_3 0.52 0.27 1.00 6 4758 1 0 0 1 16
3PDR_A 0.53 0.28 1.00 14 4826 0 0 0 0 36
3RKF_A 0.62 0.50 0.80 12 851 3 1 2 0 12
3SD1_A 0.56 0.38 0.85 11 1520 2 0 2 0 18
3W1K_J 0.47 0.26 0.89 8 1669 1 0 1 0 23
3W3S_B 0.45 0.27 0.75 9 1977 3 0 3 0 24
3ZEX_C 0.49 0.24 1.00 7 5367 0 0 0 0 22
4A1C_2 0.59 0.35 1.00 7 4509 0 0 0 0 13
4AOB_A 0.69 0.48 1.00 14 1423 1 0 0 1 15
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9
4FRG_B 0.17 0.13 0.25 3 1190 9 0 9 0 21
4FRN_A 0.66 0.50 0.88 14 1832 2 1 1 0 14
4JF2_A 0.47 0.29 0.78 7 1073 4 1 1 2 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.