CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Carnac(20)
MCC 0.625 > 0.616
Average MCC ± 95% Confidence Intervals 0.598 ± 0.338 > 0.517 ± 0.434
Sensitivity 0.587 > 0.444
Positive Predictive Value 0.673 < 0.862
Total TP 74 > 56
Total TN 11842 < 11887
Total FP 38 > 11
Total FP CONTRA 16 > 3
Total FP INCONS 20 > 6
Total FP COMP 2 = 2
Total FN 52 < 70
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 74
Total TN 11842
Total FP 38
Total FP CONTRA 16
Total FP INCONS 20
Total FP COMP 2
Total FN 52
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.598 ± 0.338
Sensitivity 0.587
Positive Predictive Value 0.673
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.19 0.20 0.19 3 2726 13 8 5 0 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3ZEX_C 0.50 0.45 0.57 13 5351 11 3 7 1 16
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 56
Total TN 11887
Total FP 11
Total FP CONTRA 3
Total FP INCONS 6
Total FP COMP 2
Total FN 70
Total Scores
MCC 0.616
Average MCC ± 95% Confidence Intervals 0.517 ± 0.434
Sensitivity 0.444
Positive Predictive Value 0.862
Nr of predictions 5

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
3ZEX_C 0.37 0.21 0.67 6 5365 4 1 2 1 23
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.