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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Cylofold [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Cylofold
MCC 0.637 > 0.557
Average MCC ± 95% Confidence Intervals 0.577 ± 0.399 > 0.563 ± 0.252
Sensitivity 0.578 > 0.509
Positive Predictive Value 0.715 > 0.626
Total TP 93 > 82
Total TN 8071 > 8070
Total FP 39 < 51
Total FP CONTRA 9 < 14
Total FP INCONS 28 < 35
Total FP COMP 2 = 2
Total FN 68 < 79
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Cylofold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Cylofold).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 93
Total TN 8071
Total FP 39
Total FP CONTRA 9
Total FP INCONS 28
Total FP COMP 2
Total FN 68
Total Scores
MCC 0.637
Average MCC ± 95% Confidence Intervals 0.577 ± 0.399
Sensitivity 0.578
Positive Predictive Value 0.715
Nr of predictions 6

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3W3S_B 0.92 0.88 0.97 29 1959 2 0 1 1 4
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10
4FRN_A 0.27 0.21 0.35 6 1831 11 2 9 0 22

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 82
Total TN 8070
Total FP 51
Total FP CONTRA 14
Total FP INCONS 35
Total FP COMP 2
Total FN 79
Total Scores
MCC 0.557
Average MCC ± 95% Confidence Intervals 0.563 ± 0.252
Sensitivity 0.509
Positive Predictive Value 0.626
Nr of predictions 6

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
3W3S_B 0.48 0.45 0.52 15 1960 15 1 13 1 18
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4FRN_A 0.23 0.18 0.31 5 1832 11 7 4 0 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.