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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Multilign(20)
MCC 0.659 > 0.578
Average MCC ± 95% Confidence Intervals 0.623 ± 0.490 > 0.544 ± 0.623
Sensitivity 0.629 > 0.588
Positive Predictive Value 0.701 > 0.582
Total TP 61 > 57
Total TN 6491 > 6480
Total FP 27 < 42
Total FP CONTRA 13 < 15
Total FP INCONS 13 < 26
Total FP COMP 1 = 1
Total FN 36 < 40
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Multilign(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 61
Total TN 6491
Total FP 27
Total FP CONTRA 13
Total FP INCONS 13
Total FP COMP 1
Total FN 36
Total Scores
MCC 0.659
Average MCC ± 95% Confidence Intervals 0.623 ± 0.490
Sensitivity 0.629
Positive Predictive Value 0.701
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.19 0.20 0.19 3 2726 13 8 5 0 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 57
Total TN 6480
Total FP 42
Total FP CONTRA 15
Total FP INCONS 26
Total FP COMP 1
Total FN 40
Total Scores
MCC 0.578
Average MCC ± 95% Confidence Intervals 0.544 ± 0.623
Sensitivity 0.588
Positive Predictive Value 0.582
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 -0.01 0.00 0.00 0 2720 22 8 14 0 15
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.