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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & Mastr(20) [.zip] - may take several seconds...


Overview

Metric Murlet(20) Mastr(20)
MCC 0.625 > 0.508
Average MCC ± 95% Confidence Intervals 0.627 ± 0.101 > 0.437 ± 0.179
Sensitivity 0.530 > 0.329
Positive Predictive Value 0.744 < 0.793
Total TP 308 > 191
Total TN 68115 < 68288
Total FP 142 > 57
Total FP CONTRA 28 > 14
Total FP INCONS 78 > 36
Total FP COMP 36 > 7
Total FN 273 < 390
P-value 5.10776592382e-08

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Performance plots


  1. Comparison of performance of Murlet(20) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Mastr(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Mastr(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Mastr(20)).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 308
Total TN 68115
Total FP 142
Total FP CONTRA 28
Total FP INCONS 78
Total FP COMP 36
Total FN 273
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.627 ± 0.101
Sensitivity 0.530
Positive Predictive Value 0.744
Nr of predictions 21

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.88 0.86 0.90 19 1087 2 0 2 0 3
3GX2_A 0.73 0.54 1.00 15 1434 1 0 0 1 13
3IVN_B 0.80 0.65 1.00 15 888 0 0 0 0 8
3IZ4_A 0.46 0.33 0.66 31 25489 22 3 13 6 64
3J20_0 0.65 0.62 0.68 13 1200 6 1 5 0 8
3J3D_C 0.84 0.84 0.84 16 949 3 3 0 0 3
3J3E_8 0.35 0.33 0.38 5 2729 13 2 6 5 10
3J3F_8 0.54 0.53 0.56 10 4743 13 2 6 5 9
3JYV_7 0.84 0.80 0.89 16 1093 4 0 2 2 4
3LA5_A 0.80 0.64 1.00 16 938 0 0 0 0 9
3NPB_A 0.65 0.43 1.00 16 2262 2 0 0 2 21
3O58_3 0.37 0.32 0.44 7 4748 13 4 5 4 15
3PDR_A 0.84 0.76 0.93 38 4799 3 1 2 0 12
3RKF_A 0.81 0.67 1.00 16 850 0 0 0 0 8
3SD1_A 0.82 0.83 0.83 24 1504 5 4 1 0 5
3ZEX_C 0.42 0.38 0.48 11 5351 16 2 10 4 18
4A1C_2 0.22 0.25 0.20 5 4491 24 5 15 4 15
4AOB_A 0.87 0.76 1.00 22 1415 3 0 0 3 7
4ENB_A 0.51 0.27 1.00 4 468 0 0 0 0 11
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10
4FRG_B 0.19 0.17 0.25 4 1186 12 1 11 0 20

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 191
Total TN 68288
Total FP 57
Total FP CONTRA 14
Total FP INCONS 36
Total FP COMP 7
Total FN 390
Total Scores
MCC 0.508
Average MCC ± 95% Confidence Intervals 0.437 ± 0.179
Sensitivity 0.329
Positive Predictive Value 0.793
Nr of predictions 21

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.81 0.77 0.85 17 1088 3 0 3 0 5
3GX2_A 0.46 0.39 0.55 11 1429 10 2 7 1 17
3IVN_B 0.86 0.83 0.90 19 882 2 2 0 0 4
3IZ4_A 0.00 0.00 0.00 0 25536 0 0 0 0 95
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3JYV_7 0.97 0.95 1.00 19 1092 2 0 0 2 1
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A 0.34 0.30 0.41 11 2251 18 1 15 2 26
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.84 0.71 1.00 17 849 0 0 0 0 7
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.42 0.34 0.53 10 1418 10 1 8 1 19
4ENB_A 0.44 0.20 1.00 3 469 0 0 0 0 12
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.