CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(seed) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric Murlet(seed) Multilign(20)
MCC 0.542 > 0.459
Average MCC ± 95% Confidence Intervals 0.540 ± 0.129 > 0.452 ± 0.234
Sensitivity 0.358 < 0.468
Positive Predictive Value 0.829 > 0.461
Total TP 68 < 89
Total TN 17943 > 17832
Total FP 17 < 127
Total FP CONTRA 1 < 34
Total FP INCONS 13 < 70
Total FP COMP 3 < 23
Total FN 122 > 101
P-value 0.0

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Performance plots


  1. Comparison of performance of Murlet(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and Multilign(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and Multilign(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and Multilign(20)).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 68
Total TN 17943
Total FP 17
Total FP CONTRA 1
Total FP INCONS 13
Total FP COMP 3
Total FN 122
Total Scores
MCC 0.542
Average MCC ± 95% Confidence Intervals 0.540 ± 0.129
Sensitivity 0.358
Positive Predictive Value 0.829
Nr of predictions 9

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.36 0.13 1.00 2 2740 2 0 0 2 13
3J3F_8 0.61 0.37 1.00 7 4754 0 0 0 0 12
3RKF_A 0.62 0.50 0.80 12 851 3 1 2 0 12
3SD1_A 0.56 0.38 0.85 11 1520 2 0 2 0 18
4A1C_2 0.59 0.35 1.00 7 4509 0 0 0 0 13
4AOB_A 0.69 0.48 1.00 14 1423 1 0 0 1 15
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9
4FRG_B 0.17 0.13 0.25 3 1190 9 0 9 0 21

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 89
Total TN 17832
Total FP 127
Total FP CONTRA 34
Total FP INCONS 70
Total FP COMP 23
Total FN 101
Total Scores
MCC 0.459
Average MCC ± 95% Confidence Intervals 0.452 ± 0.234
Sensitivity 0.468
Positive Predictive Value 0.461
Nr of predictions 9

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 -0.01 0.00 0.00 0 2720 22 8 14 0 15
3J3F_8 0.45 0.53 0.38 10 4735 30 7 9 14 9
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6
4FRG_B 0.13 0.13 0.17 3 1184 15 2 13 0 21

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.