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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(seed) - scored higher in this pairwise comparison

  4. Performance of RSpredict(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(seed) & RSpredict(20) [.zip] - may take several seconds...


Overview

Metric Murlet(seed) RSpredict(20)
MCC 0.564 > 0.508
Average MCC ± 95% Confidence Intervals 0.561 ± 0.072 > 0.479 ± 0.165
Sensitivity 0.366 < 0.453
Positive Predictive Value 0.876 > 0.579
Total TP 148 < 183
Total TN 38418 > 38271
Total FP 28 < 161
Total FP CONTRA 4 < 56
Total FP INCONS 17 < 77
Total FP COMP 7 < 28
Total FN 256 > 221
P-value 1.77512146924e-08

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Performance plots


  1. Comparison of performance of Murlet(seed) and RSpredict(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and RSpredict(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(20)).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 148
Total TN 38418
Total FP 28
Total FP CONTRA 4
Total FP INCONS 17
Total FP COMP 7
Total FN 256
Total Scores
MCC 0.564
Average MCC ± 95% Confidence Intervals 0.561 ± 0.072
Sensitivity 0.366
Positive Predictive Value 0.876
Nr of predictions 16

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3GX2_A 0.70 0.50 1.00 14 1435 1 0 0 1 14
3IVN_B 0.62 0.52 0.75 12 887 4 2 2 0 11
3J3E_8 0.36 0.13 1.00 2 2740 2 0 0 2 13
3J3F_8 0.61 0.37 1.00 7 4754 0 0 0 0 12
3LA5_A 0.67 0.56 0.82 14 937 3 1 2 0 11
3NPB_A 0.59 0.35 1.00 13 2265 2 0 0 2 24
3O58_3 0.52 0.27 1.00 6 4758 1 0 0 1 16
3PDR_A 0.53 0.28 1.00 14 4826 0 0 0 0 36
3RKF_A 0.62 0.50 0.80 12 851 3 1 2 0 12
3SD1_A 0.56 0.38 0.85 11 1520 2 0 2 0 18
3ZEX_C 0.49 0.24 1.00 7 5367 0 0 0 0 22
4A1C_2 0.59 0.35 1.00 7 4509 0 0 0 0 13
4AOB_A 0.69 0.48 1.00 14 1423 1 0 0 1 15
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9
4FRG_B 0.17 0.13 0.25 3 1190 9 0 9 0 21

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Performance of RSpredict(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 183
Total TN 38271
Total FP 161
Total FP CONTRA 56
Total FP INCONS 77
Total FP COMP 28
Total FN 221
Total Scores
MCC 0.508
Average MCC ± 95% Confidence Intervals 0.479 ± 0.165
Sensitivity 0.453
Positive Predictive Value 0.579
Nr of predictions 16

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3GX2_A 0.40 0.21 0.75 6 1441 2 1 1 0 22
3IVN_B 0.91 0.87 0.95 20 882 1 1 0 0 3
3J3E_8 -0.01 0.00 0.00 0 2724 19 5 13 1 15
3J3F_8 0.42 0.47 0.38 9 4737 26 9 6 11 10
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A -0.01 0.00 0.00 0 2272 6 1 5 0 37
3O58_3 0.38 0.50 0.30 11 4727 29 15 11 3 11
3PDR_A 0.80 0.70 0.92 35 4802 5 1 2 2 15
3RKF_A 0.91 0.88 0.95 21 844 1 1 0 0 3
3SD1_A 0.82 0.86 0.78 25 1501 7 5 2 0 4
3ZEX_C 0.34 0.31 0.38 9 5350 19 3 12 4 20
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9
4FRG_B 0.19 0.13 0.33 3 1193 6 1 5 0 21

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.