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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of Alterna - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & Alterna [.zip] - may take several seconds...


Overview

Metric NanoFolder Alterna
MCC 0.536 > 0.471
Average MCC ± 95% Confidence Intervals 0.536 ± > 0.471 ±
Sensitivity 0.611 > 0.444
Positive Predictive Value 0.500 < 0.533
Total TP 11 > 8
Total TN 506 < 513
Total FP 11 > 7
Total FP CONTRA 1 > 0
Total FP INCONS 10 > 7
Total FP COMP 0 = 0
Total FN 7 < 10
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and Alterna. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and Alterna).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and Alterna. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and Alterna).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 11
Total TN 506
Total FP 11
Total FP CONTRA 1
Total FP INCONS 10
Total FP COMP 0
Total FN 7
Total Scores
MCC 0.536
Average MCC ± 95% Confidence Intervals 0.536 ±
Sensitivity 0.611
Positive Predictive Value 0.500
Nr of predictions 1

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A

GP_knot1 links to Rfam database...

0.54 0.61 0.50 11 506 11 1 10 0 7

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Performance of Alterna - scored lower in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 8
Total TN 513
Total FP 7
Total FP CONTRA 0
Total FP INCONS 7
Total FP COMP 0
Total FN 10
Total Scores
MCC 0.471
Average MCC ± 95% Confidence Intervals 0.471 ±
Sensitivity 0.444
Positive Predictive Value 0.533
Nr of predictions 1

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A

GP_knot1 links to Rfam database...

0.47 0.44 0.53 8 513 7 0 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

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