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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) TurboFold(seed)
MCC 0.490 > 0.468
Average MCC ± 95% Confidence Intervals 0.499 ± 0.217 < 0.507 ± 0.207
Sensitivity 0.465 < 0.479
Positive Predictive Value 0.524 > 0.466
Total TP 66 < 68
Total TN 19672 > 19652
Total FP 88 < 122
Total FP CONTRA 10 < 29
Total FP INCONS 50 > 49
Total FP COMP 28 < 44
Total FN 76 > 74
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and TurboFold(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and TurboFold(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and TurboFold(seed)).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 66
Total TN 19672
Total FP 88
Total FP CONTRA 10
Total FP INCONS 50
Total FP COMP 28
Total FN 76
Total Scores
MCC 0.490
Average MCC ± 95% Confidence Intervals 0.499 ± 0.217
Sensitivity 0.465
Positive Predictive Value 0.524
Nr of predictions 7

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.48 0.47 0.50 7 2728 11 2 5 4 8
3J3F_8 0.34 0.37 0.32 7 4739 24 5 10 9 12
3ZEX_C 0.26 0.24 0.29 7 5350 20 1 16 3 22
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 68
Total TN 19652
Total FP 122
Total FP CONTRA 29
Total FP INCONS 49
Total FP COMP 44
Total FN 74
Total Scores
MCC 0.468
Average MCC ± 95% Confidence Intervals 0.507 ± 0.207
Sensitivity 0.479
Positive Predictive Value 0.466
Nr of predictions 7

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.27 0.33 0.23 5 2720 28 6 11 11 10
3J3F_8 0.42 0.53 0.34 10 4732 35 9 10 16 9
3ZEX_C 0.49 0.45 0.54 13 5350 15 2 9 4 16
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.