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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric PPfold(20) Multilign(seed)
MCC 0.673 > 0.625
Average MCC ± 95% Confidence Intervals 0.628 ± 0.385 > 0.598 ± 0.338
Sensitivity 0.611 > 0.587
Positive Predictive Value 0.748 > 0.673
Total TP 77 > 74
Total TN 11849 > 11842
Total FP 35 < 38
Total FP CONTRA 4 < 16
Total FP INCONS 22 > 20
Total FP COMP 9 > 2
Total FN 49 < 52
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and Multilign(seed)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 77
Total TN 11849
Total FP 35
Total FP CONTRA 4
Total FP INCONS 22
Total FP COMP 9
Total FN 49
Total Scores
MCC 0.673
Average MCC ± 95% Confidence Intervals 0.628 ± 0.385
Sensitivity 0.611
Positive Predictive Value 0.748
Nr of predictions 5

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.21 0.20 0.23 3 2729 13 2 8 3 12
3RKF_A 0.86 0.79 0.95 19 846 1 0 1 0 5
3SD1_A 0.81 0.76 0.88 22 1508 3 2 1 0 7
3ZEX_C 0.38 0.31 0.47 9 5355 14 0 10 4 20
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 74
Total TN 11842
Total FP 38
Total FP CONTRA 16
Total FP INCONS 20
Total FP COMP 2
Total FN 52
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.598 ± 0.338
Sensitivity 0.587
Positive Predictive Value 0.673
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.19 0.20 0.19 3 2726 13 8 5 0 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3ZEX_C 0.50 0.45 0.57 13 5351 11 3 7 1 16
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.