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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of RSpredict(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & RSpredict(20) [.zip] - may take several seconds...


Overview

Metric RNASampler(20) RSpredict(20)
MCC 0.692 > 0.585
Average MCC ± 95% Confidence Intervals 0.707 ± 0.111 > 0.564 ± 0.144
Sensitivity 0.621 > 0.534
Positive Predictive Value 0.776 > 0.649
Total TP 361 > 310
Total TN 68064 > 68051
Total FP 165 < 210
Total FP CONTRA 42 < 73
Total FP INCONS 62 < 95
Total FP COMP 61 > 42
Total FN 220 < 271
P-value 5.19332990918e-08

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Performance plots


  1. Comparison of performance of RNASampler(20) and RSpredict(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RSpredict(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(20)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 361
Total TN 68064
Total FP 165
Total FP CONTRA 42
Total FP INCONS 62
Total FP COMP 61
Total FN 220
Total Scores
MCC 0.692
Average MCC ± 95% Confidence Intervals 0.707 ± 0.111
Sensitivity 0.621
Positive Predictive Value 0.776
Nr of predictions 21

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.98 0.95 1.00 21 1087 0 0 0 0 1
3GX2_A 0.88 0.79 1.00 22 1427 1 0 0 1 6
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IZ4_A 0.52 0.41 0.65 39 25476 26 15 6 5 56
3J20_0 0.90 0.90 0.90 19 1198 3 1 1 1 2
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.19 0.20 0.19 3 2726 21 5 8 8 12
3J3F_8 0.43 0.47 0.39 9 4738 20 6 8 6 10
3JYV_7 0.97 0.95 1.00 19 1092 2 0 0 2 1
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A 0.75 0.57 1.00 21 2257 5 0 0 5 16
3O58_3 0.51 0.50 0.52 11 4743 19 5 5 9 11
3PDR_A 0.84 0.76 0.93 38 4799 5 1 2 2 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.81 0.69 0.95 20 1512 1 0 1 0 9
3ZEX_C 0.35 0.31 0.39 9 5351 21 3 11 7 20
4A1C_2 0.24 0.25 0.24 5 4495 30 3 13 14 15
4AOB_A 0.70 0.59 0.85 17 1417 4 0 3 1 12
4ENB_A 0.68 0.47 1.00 7 465 0 0 0 0 8
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4
4FRG_B 0.64 0.54 0.76 13 1185 4 0 4 0 11

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Performance of RSpredict(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 310
Total TN 68051
Total FP 210
Total FP CONTRA 73
Total FP INCONS 95
Total FP COMP 42
Total FN 271
Total Scores
MCC 0.585
Average MCC ± 95% Confidence Intervals 0.564 ± 0.144
Sensitivity 0.534
Positive Predictive Value 0.649
Nr of predictions 21

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.88 0.86 0.90 19 1087 2 0 2 0 3
3GX2_A 0.40 0.21 0.75 6 1441 2 1 1 0 22
3IVN_B 0.91 0.87 0.95 20 882 1 1 0 0 3
3IZ4_A 0.61 0.57 0.67 54 25455 38 13 14 11 41
3J20_0 0.90 0.90 0.90 19 1198 3 1 1 1 2
3J3D_C 0.82 0.84 0.80 16 948 4 3 1 0 3
3J3E_8 -0.01 0.00 0.00 0 2724 19 5 13 1 15
3J3F_8 0.42 0.47 0.38 9 4737 26 9 6 11 10
3JYV_7 0.97 0.95 1.00 19 1092 2 0 0 2 1
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A -0.01 0.00 0.00 0 2272 6 1 5 0 37
3O58_3 0.38 0.50 0.30 11 4727 29 15 11 3 11
3PDR_A 0.80 0.70 0.92 35 4802 5 1 2 2 15
3RKF_A 0.91 0.88 0.95 21 844 1 1 0 0 3
3SD1_A 0.82 0.86 0.78 25 1501 7 5 2 0 4
3ZEX_C 0.34 0.31 0.38 9 5350 19 3 12 4 20
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9
4FRG_B 0.19 0.13 0.33 3 1193 6 1 5 0 21

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.