CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & Vsfold4 [.zip] - may take several seconds...


Overview

Metric RNASampler(20) Vsfold4
MCC 0.710 > 0.537
Average MCC ± 95% Confidence Intervals 0.725 ± 0.110 > 0.566 ± 0.144
Sensitivity 0.638 > 0.531
Positive Predictive Value 0.796 > 0.551
Total TP 352 > 293
Total TN 62713 > 62623
Total FP 144 < 297
Total FP CONTRA 39 < 70
Total FP INCONS 51 < 169
Total FP COMP 54 < 58
Total FN 200 < 259
P-value 5.10776592382e-08

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Performance plots


  1. Comparison of performance of RNASampler(20) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Vsfold4).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 352
Total TN 62713
Total FP 144
Total FP CONTRA 39
Total FP INCONS 51
Total FP COMP 54
Total FN 200
Total Scores
MCC 0.710
Average MCC ± 95% Confidence Intervals 0.725 ± 0.110
Sensitivity 0.638
Positive Predictive Value 0.796
Nr of predictions 20

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.98 0.95 1.00 21 1087 0 0 0 0 1
3GX2_A 0.88 0.79 1.00 22 1427 1 0 0 1 6
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IZ4_A 0.52 0.41 0.65 39 25476 26 15 6 5 56
3J20_0 0.90 0.90 0.90 19 1198 3 1 1 1 2
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.19 0.20 0.19 3 2726 21 5 8 8 12
3J3F_8 0.43 0.47 0.39 9 4738 20 6 8 6 10
3JYV_7 0.97 0.95 1.00 19 1092 2 0 0 2 1
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A 0.75 0.57 1.00 21 2257 5 0 0 5 16
3O58_3 0.51 0.50 0.52 11 4743 19 5 5 9 11
3PDR_A 0.84 0.76 0.93 38 4799 5 1 2 2 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.81 0.69 0.95 20 1512 1 0 1 0 9
4A1C_2 0.24 0.25 0.24 5 4495 30 3 13 14 15
4AOB_A 0.70 0.59 0.85 17 1417 4 0 3 1 12
4ENB_A 0.68 0.47 1.00 7 465 0 0 0 0 8
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4
4FRG_B 0.64 0.54 0.76 13 1185 4 0 4 0 11

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 293
Total TN 62623
Total FP 297
Total FP CONTRA 70
Total FP INCONS 169
Total FP COMP 58
Total FN 259
Total Scores
MCC 0.537
Average MCC ± 95% Confidence Intervals 0.566 ± 0.144
Sensitivity 0.531
Positive Predictive Value 0.551
Nr of predictions 20

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3GX2_A 0.60 0.57 0.64 16 1424 10 0 9 1 12
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IZ4_A 0.39 0.39 0.39 37 25441 63 15 43 5 58
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J3D_C 0.48 0.53 0.45 10 946 12 4 8 0 9
3J3E_8 0.10 0.13 0.09 2 2720 32 9 11 12 13
3J3F_8 0.35 0.42 0.30 8 4734 30 11 8 11 11
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.66 0.59 0.73 22 2248 10 0 8 2 15
3O58_3 0.12 0.14 0.11 3 4737 35 8 16 11 19
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.23 0.24 0.24 7 1504 22 5 17 0 22
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.