CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & Vsfold5 [.zip] - may take several seconds...


Overview

Metric RNASampler(20) Vsfold5
MCC 0.710 > 0.493
Average MCC ± 95% Confidence Intervals 0.725 ± 0.110 > 0.526 ± 0.156
Sensitivity 0.638 > 0.493
Positive Predictive Value 0.796 > 0.502
Total TP 352 > 272
Total TN 62713 > 62613
Total FP 144 < 334
Total FP CONTRA 39 < 84
Total FP INCONS 51 < 186
Total FP COMP 54 < 64
Total FN 200 < 280
P-value 5.1503931209e-08

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Performance plots


  1. Comparison of performance of RNASampler(20) and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 352
Total TN 62713
Total FP 144
Total FP CONTRA 39
Total FP INCONS 51
Total FP COMP 54
Total FN 200
Total Scores
MCC 0.710
Average MCC ± 95% Confidence Intervals 0.725 ± 0.110
Sensitivity 0.638
Positive Predictive Value 0.796
Nr of predictions 20

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.98 0.95 1.00 21 1087 0 0 0 0 1
3GX2_A 0.88 0.79 1.00 22 1427 1 0 0 1 6
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IZ4_A 0.52 0.41 0.65 39 25476 26 15 6 5 56
3J20_0 0.90 0.90 0.90 19 1198 3 1 1 1 2
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.19 0.20 0.19 3 2726 21 5 8 8 12
3J3F_8 0.43 0.47 0.39 9 4738 20 6 8 6 10
3JYV_7 0.97 0.95 1.00 19 1092 2 0 0 2 1
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A 0.75 0.57 1.00 21 2257 5 0 0 5 16
3O58_3 0.51 0.50 0.52 11 4743 19 5 5 9 11
3PDR_A 0.84 0.76 0.93 38 4799 5 1 2 2 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.81 0.69 0.95 20 1512 1 0 1 0 9
4A1C_2 0.24 0.25 0.24 5 4495 30 3 13 14 15
4AOB_A 0.70 0.59 0.85 17 1417 4 0 3 1 12
4ENB_A 0.68 0.47 1.00 7 465 0 0 0 0 8
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4
4FRG_B 0.64 0.54 0.76 13 1185 4 0 4 0 11

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 272
Total TN 62613
Total FP 334
Total FP CONTRA 84
Total FP INCONS 186
Total FP COMP 64
Total FN 280
Total Scores
MCC 0.493
Average MCC ± 95% Confidence Intervals 0.526 ± 0.156
Sensitivity 0.493
Positive Predictive Value 0.502
Nr of predictions 20

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3GX2_A 0.61 0.57 0.67 16 1425 9 0 8 1 12
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IZ4_A 0.31 0.31 0.33 29 25448 65 14 45 6 66
3J20_0 0.76 0.76 0.76 16 1198 6 3 2 1 5
3J3D_C 0.63 0.68 0.59 13 946 9 3 6 0 6
3J3E_8 0.10 0.13 0.08 2 2718 31 10 12 9 13
3J3F_8 0.36 0.47 0.27 9 4728 38 13 11 14 10
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3LA5_A -0.02 0.00 0.00 0 938 16 0 16 0 25
3NPB_A 0.62 0.54 0.71 20 2250 10 1 7 2 17
3O58_3 0.51 0.59 0.45 13 4735 28 11 5 12 9
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.