CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(seed) & Mastr(20) [.zip] - may take several seconds...


Overview

Metric RNASampler(seed) Mastr(20)
MCC 0.576 > 0.520
Average MCC ± 95% Confidence Intervals 0.564 ± 0.217 > 0.304 ± 0.352
Sensitivity 0.525 > 0.315
Positive Predictive Value 0.638 < 0.864
Total TP 95 > 57
Total TN 25310 < 25393
Total FP 88 > 9
Total FP CONTRA 21 > 6
Total FP INCONS 33 > 3
Total FP COMP 34 > 0
Total FN 86 < 124
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(seed) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and Mastr(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and Mastr(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and Mastr(20)).

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Performance of RNASampler(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 95
Total TN 25310
Total FP 88
Total FP CONTRA 21
Total FP INCONS 33
Total FP COMP 34
Total FN 86
Total Scores
MCC 0.576
Average MCC ± 95% Confidence Intervals 0.564 ± 0.217
Sensitivity 0.525
Positive Predictive Value 0.638
Nr of predictions 8

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3J3E_8 0.18 0.20 0.18 3 2725 22 5 9 8 12
3J3F_8 0.47 0.47 0.47 9 4742 18 5 5 8 10
3O58_3 0.54 0.50 0.58 11 4745 13 5 3 5 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
3ZEX_C 0.39 0.31 0.50 9 5356 14 2 7 5 20
4A1C_2 0.40 0.40 0.40 8 4496 20 4 8 8 12

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 57
Total TN 25393
Total FP 9
Total FP CONTRA 6
Total FP INCONS 3
Total FP COMP 0
Total FN 124
Total Scores
MCC 0.520
Average MCC ± 95% Confidence Intervals 0.304 ± 0.352
Sensitivity 0.315
Positive Predictive Value 0.864
Nr of predictions 8

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3IVN_B 0.86 0.83 0.90 19 882 2 2 0 0 4
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3RKF_A 0.84 0.71 1.00 17 849 0 0 0 0 7
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.