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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(20) - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(20) & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric RNAalifold(20) CMfinder(20)
MCC 0.727 > 0.580
Average MCC ± 95% Confidence Intervals 0.708 ± 0.320 > 0.564 ± 0.352
Sensitivity 0.714 > 0.500
Positive Predictive Value 0.745 > 0.681
Total TP 70 > 49
Total TN 10798 < 10820
Total FP 33 > 26
Total FP CONTRA 11 < 12
Total FP INCONS 13 > 11
Total FP COMP 9 > 3
Total FN 28 < 49
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(20) and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and CMfinder(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and CMfinder(20)).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 70
Total TN 10798
Total FP 33
Total FP CONTRA 11
Total FP INCONS 13
Total FP COMP 9
Total FN 28
Total Scores
MCC 0.727
Average MCC ± 95% Confidence Intervals 0.708 ± 0.320
Sensitivity 0.714
Positive Predictive Value 0.745
Nr of predictions 5

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.95 0.95 0.95 20 1198 1 1 0 0 1
3J3D_C 0.87 0.89 0.85 17 948 3 3 0 0 2
3J3E_8 0.34 0.33 0.36 5 2728 9 3 6 0 10
3J3F_8 0.54 0.58 0.50 11 4739 20 4 7 9 8
4FRG_B 0.84 0.71 1.00 17 1185 0 0 0 0 7

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 49
Total TN 10820
Total FP 26
Total FP CONTRA 12
Total FP INCONS 11
Total FP COMP 3
Total FN 49
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.564 ± 0.352
Sensitivity 0.500
Positive Predictive Value 0.681
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J3D_C 0.81 0.79 0.83 15 950 3 3 0 0 4
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.