CompaRNA - on-line benchmarks of RNA structure prediction methods
Home

Methods
Datasets
Rankings
RNA 2D Atlas

Help
FAQ

Contact us
RSS feeds
Twitter

Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(20) Carnac(seed)
MCC 0.705 > 0.000
Average MCC ± 95% Confidence Intervals 0.674 ± 0.122 > 0.000 ± 0.000
Sensitivity 0.636 > 0.000
Positive Predictive Value 0.788 > 0.000
Total TP 257 > 0
Total TN 38261 < 38587
Total FP 94 > 0
Total FP CONTRA 23 > 0
Total FP INCONS 46 > 0
Total FP COMP 25 > 0
Total FN 147 < 404
P-value 2.54914456376e-08

^top




Performance plots


  1. Comparison of performance of RNAalifold(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and Carnac(seed)).

^top





Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 257
Total TN 38261
Total FP 94
Total FP CONTRA 23
Total FP INCONS 46
Total FP COMP 25
Total FN 147
Total Scores
MCC 0.705
Average MCC ± 95% Confidence Intervals 0.674 ± 0.122
Sensitivity 0.636
Positive Predictive Value 0.788
Nr of predictions 16

^top



2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3GX2_A 0.92 0.86 1.00 24 1425 1 0 0 1 4
3IVN_B 0.86 0.78 0.95 18 884 1 1 0 0 5
3J3E_8 0.34 0.33 0.36 5 2728 9 3 6 0 10
3J3F_8 0.54 0.58 0.50 11 4739 20 4 7 9 8
3LA5_A 0.87 0.76 1.00 19 935 0 0 0 0 6
3NPB_A 0.75 0.57 1.00 21 2257 4 0 0 4 16
3O58_3 0.42 0.36 0.50 8 4748 9 3 5 1 14
3PDR_A 0.92 0.88 0.96 44 4794 3 1 1 1 6
3RKF_A 0.81 0.71 0.94 17 848 1 0 1 0 7
3SD1_A 0.84 0.86 0.83 25 1503 5 4 1 0 4
3ZEX_C 0.46 0.41 0.52 12 5351 16 2 9 5 17
4A1C_2 0.22 0.25 0.19 5 4490 23 5 16 2 15
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8
4ENB_A 0.51 0.27 1.00 4 468 0 0 0 0 11
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9
4FRG_B 0.84 0.71 1.00 17 1185 0 0 0 0 7

^top



Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 0
Total TN 38587
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 404
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 16

^top



2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

^top


Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.