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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(20) Multilign(seed)
MCC 0.689 > 0.625
Average MCC ± 95% Confidence Intervals 0.662 ± 0.300 > 0.598 ± 0.338
Sensitivity 0.635 > 0.587
Positive Predictive Value 0.755 > 0.673
Total TP 80 > 74
Total TN 11846 > 11842
Total FP 33 < 38
Total FP CONTRA 9 < 16
Total FP INCONS 17 < 20
Total FP COMP 7 > 2
Total FN 46 < 52
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and Multilign(seed)).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 80
Total TN 11846
Total FP 33
Total FP CONTRA 9
Total FP INCONS 17
Total FP COMP 7
Total FN 46
Total Scores
MCC 0.689
Average MCC ± 95% Confidence Intervals 0.662 ± 0.300
Sensitivity 0.635
Positive Predictive Value 0.755
Nr of predictions 5

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.34 0.33 0.36 5 2728 9 3 6 0 10
3RKF_A 0.81 0.71 0.94 17 848 1 0 1 0 7
3SD1_A 0.84 0.86 0.83 25 1503 5 4 1 0 4
3ZEX_C 0.46 0.41 0.52 12 5351 16 2 9 5 17
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 74
Total TN 11842
Total FP 38
Total FP CONTRA 16
Total FP INCONS 20
Total FP COMP 2
Total FN 52
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.598 ± 0.338
Sensitivity 0.587
Positive Predictive Value 0.673
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.19 0.20 0.19 3 2726 13 8 5 0 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3ZEX_C 0.50 0.45 0.57 13 5351 11 3 7 1 16
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.