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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(seed) - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(seed) & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric RNAalifold(seed) CMfinder(20)
MCC 0.642 > 0.385
Average MCC ± 95% Confidence Intervals 0.482 ± 1.076 > 0.389 ± 0.528
Sensitivity 0.414 > 0.310
Positive Predictive Value 1.000 > 0.486
Total TP 24 > 18
Total TN 8681 > 8668
Total FP 2 < 21
Total FP CONTRA 0 < 8
Total FP INCONS 0 < 11
Total FP COMP 2 = 2
Total FN 34 < 40
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(seed) and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and CMfinder(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and CMfinder(20)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 24
Total TN 8681
Total FP 2
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 2
Total FN 34
Total Scores
MCC 0.642
Average MCC ± 95% Confidence Intervals 0.482 ± 1.076
Sensitivity 0.414
Positive Predictive Value 1.000
Nr of predictions 3

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.61 0.37 1.00 7 4754 2 0 0 2 12
4FRG_B 0.84 0.71 1.00 17 1185 0 0 0 0 7

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 18
Total TN 8668
Total FP 21
Total FP CONTRA 8
Total FP INCONS 11
Total FP COMP 2
Total FN 40
Total Scores
MCC 0.385
Average MCC ± 95% Confidence Intervals 0.389 ± 0.528
Sensitivity 0.310
Positive Predictive Value 0.486
Nr of predictions 3

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.14 0.13 0.17 2 2730 10 3 7 0 13
3J3F_8 0.48 0.47 0.50 9 4743 11 5 4 2 10
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.