CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAsubopt - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAsubopt & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric RNAsubopt Carnac(seed)
MCC 0.639 > 0.200
Average MCC ± 95% Confidence Intervals 0.614 ± 0.134 > 0.061 ± 0.093
Sensitivity 0.657 > 0.040
Positive Predictive Value 0.630 < 1.000
Total TP 373 > 23
Total TN 46620 < 47189
Total FP 301 > 0
Total FP CONTRA 71 > 0
Total FP INCONS 148 > 0
Total FP COMP 82 > 0
Total FN 195 < 545
P-value 5.19332990918e-08

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Performance plots


  1. Comparison of performance of RNAsubopt and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Carnac(seed)).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 373
Total TN 46620
Total FP 301
Total FP CONTRA 71
Total FP INCONS 148
Total FP COMP 82
Total FN 195
Total Scores
MCC 0.639
Average MCC ± 95% Confidence Intervals 0.614 ± 0.134
Sensitivity 0.657
Positive Predictive Value 0.630
Nr of predictions 22

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3GX2_A 0.53 0.54 0.54 15 1421 14 4 9 1 13
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3J3E_8 0.25 0.33 0.20 5 2717 32 7 13 12 10
3J3F_8 0.35 0.47 0.26 9 4726 42 13 13 16 10
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.84 0.78 0.91 29 2246 8 0 3 5 8
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3W1K_J 0.97 0.97 0.97 30 1647 1 1 0 0 1
3W3S_B 0.95 0.94 0.97 31 1957 2 0 1 1 2
3ZEX_C 0.30 0.34 0.26 10 5336 43 5 23 15 19
4A1C_2 0.18 0.25 0.14 5 4481 43 13 17 13 15
4AOB_A 0.62 0.62 0.64 18 1409 11 4 6 1 11
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.36 0.33 0.42 5 484 7 0 7 0 10
4FRG_B 0.36 0.38 0.38 9 1178 15 2 13 0 15
4FRN_A 0.58 0.57 0.59 16 1821 11 3 8 0 12
4JF2_A 0.69 0.67 0.73 16 1060 6 4 2 0 8

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 23
Total TN 47189
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 545
Total Scores
MCC 0.200
Average MCC ± 95% Confidence Intervals 0.061 ± 0.093
Sensitivity 0.040
Positive Predictive Value 1.000
Nr of predictions 22

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.22 1.00 4 524 0 0 0 0 14
3A3A_A 0.00 0.00 0.00 0 1500 0 0 0 0 30
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W1K_J 0.00 0.00 0.00 0 1678 0 0 0 0 31
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24
4FRN_A 0.00 0.00 0.00 0 1848 0 0 0 0 28
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.