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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Afold [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Afold
MCC 0.519 > 0.501
Average MCC ± 95% Confidence Intervals 0.544 ± 0.553 > 0.544 ± 0.592
Sensitivity 0.527 < 0.554
Positive Predictive Value 0.520 > 0.461
Total TP 39 < 41
Total TN 8521 > 8507
Total FP 56 < 77
Total FP CONTRA 12 < 17
Total FP INCONS 24 < 31
Total FP COMP 20 < 29
Total FN 35 > 33
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Afold).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 39
Total TN 8521
Total FP 56
Total FP CONTRA 12
Total FP INCONS 24
Total FP COMP 20
Total FN 35
Total Scores
MCC 0.519
Average MCC ± 95% Confidence Intervals 0.544 ± 0.553
Sensitivity 0.527
Positive Predictive Value 0.520
Nr of predictions 4

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.27 0.33 0.23 5 2720 28 6 11 11 10
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 41
Total TN 8507
Total FP 77
Total FP CONTRA 17
Total FP INCONS 31
Total FP COMP 29
Total FN 33
Total Scores
MCC 0.501
Average MCC ± 95% Confidence Intervals 0.544 ± 0.592
Sensitivity 0.554
Positive Predictive Value 0.461
Nr of predictions 4

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.26 0.33 0.21 5 2718 31 6 13 12 10
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.19 0.25 0.15 5 4483 43 11 17 15 15
4ENB_A 0.81 0.73 0.92 11 460 3 0 1 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.