CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold4 Carnac(seed)
MCC 0.585 > 0.218
Average MCC ± 95% Confidence Intervals 0.577 ± 0.147 > 0.071 ± 0.108
Sensitivity 0.567 > 0.048
Positive Predictive Value 0.614 < 1.000
Total TP 272 > 23
Total TN 37869 < 38289
Total FP 224 > 0
Total FP CONTRA 47 > 0
Total FP INCONS 124 > 0
Total FP COMP 53 > 0
Total FN 208 < 457
P-value 2.64318034126e-08

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Performance plots


  1. Comparison of performance of Vsfold4 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 272
Total TN 37869
Total FP 224
Total FP CONTRA 47
Total FP INCONS 124
Total FP COMP 53
Total FN 208
Total Scores
MCC 0.585
Average MCC ± 95% Confidence Intervals 0.577 ± 0.147
Sensitivity 0.567
Positive Predictive Value 0.614
Nr of predictions 19

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3GX2_A 0.60 0.57 0.64 16 1424 10 0 9 1 12
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3J3E_8 0.10 0.13 0.09 2 2720 32 9 11 12 13
3J3F_8 0.35 0.42 0.30 8 4734 30 11 8 11 11
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.66 0.59 0.73 22 2248 10 0 8 2 15
3O58_3 0.12 0.14 0.11 3 4737 35 8 16 11 19
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.23 0.24 0.24 7 1504 22 5 17 0 22
3W3S_B 0.74 0.70 0.79 23 1960 7 1 5 1 10
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10
4JF2_A 0.74 0.67 0.84 16 1063 3 0 3 0 8

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 23
Total TN 38289
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 457
Total Scores
MCC 0.218
Average MCC ± 95% Confidence Intervals 0.071 ± 0.108
Sensitivity 0.048
Positive Predictive Value 1.000
Nr of predictions 19

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.22 1.00 4 524 0 0 0 0 14
3A3A_A 0.00 0.00 0.00 0 1500 0 0 0 0 30
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.