CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of RNAwolf - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & RNAwolf [.zip] - may take several seconds...


Overview

Metric Vsfold4 RNAwolf
MCC 0.504 > 0.488
Average MCC ± 95% Confidence Intervals 0.481 ± 0.142 > 0.462 ± 0.135
Sensitivity 0.497 = 0.497
Positive Predictive Value 0.524 > 0.492
Total TP 186 = 186
Total TN 26529 > 26506
Total FP 208 < 241
Total FP CONTRA 53 < 55
Total FP INCONS 116 < 137
Total FP COMP 39 < 49
Total FN 188 = 188
P-value 6.52442735156e-07

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Performance plots


  1. Comparison of performance of Vsfold4 and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and RNAwolf).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and RNAwolf).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and RNAwolf).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 186
Total TN 26529
Total FP 208
Total FP CONTRA 53
Total FP INCONS 116
Total FP COMP 39
Total FN 188
Total Scores
MCC 0.504
Average MCC ± 95% Confidence Intervals 0.481 ± 0.142
Sensitivity 0.497
Positive Predictive Value 0.524
Nr of predictions 19

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2M58_A - -0.02 0.00 0.00 0 538 6 0 6 0 12
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J3D_C 0.48 0.53 0.45 10 946 12 4 8 0 9
3J3E_8 0.10 0.13 0.09 2 2720 32 9 11 12 13
3J3F_8 0.35 0.42 0.30 8 4734 30 11 8 11 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.23 0.24 0.24 7 1504 22 5 17 0 22
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3W3S_B 0.74 0.70 0.79 23 1960 7 1 5 1 10
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ATO_G - 0.38 0.43 0.38 3 212 5 5 0 0 4
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10
4JF2_A 0.74 0.67 0.84 16 1063 3 0 3 0 8
4JRC_A - 0.34 0.29 0.42 5 610 7 0 7 0 12

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP 186
Total TN 26506
Total FP 241
Total FP CONTRA 55
Total FP INCONS 137
Total FP COMP 49
Total FN 188
Total Scores
MCC 0.488
Average MCC ± 95% Confidence Intervals 0.462 ± 0.135
Sensitivity 0.497
Positive Predictive Value 0.492
Nr of predictions 19

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.52 0.50 0.56 9 512 7 0 7 0 9
2M58_A - 0.60 0.58 0.64 7 533 4 1 3 0 5
3J0L_a - 0.14 0.18 0.14 2 397 13 4 8 1 9
3J20_0 0.54 0.57 0.52 12 1196 12 2 9 1 9
3J3D_C 0.92 0.95 0.90 18 948 3 2 0 1 1
3J3E_8 -0.01 0.00 0.00 0 2719 37 6 17 14 15
3J3F_8 0.28 0.37 0.23 7 4730 39 9 15 15 12
3RKF_A 0.89 0.83 0.95 20 845 1 0 1 0 4
3SD1_A 0.58 0.59 0.59 17 1504 12 2 10 0 12
3U4M_B - 0.50 0.50 0.52 11 1255 12 1 9 2 11
3W3S_B 0.70 0.70 0.72 23 1957 10 0 9 1 10
4A1C_2 0.12 0.15 0.10 3 4487 38 12 14 12 17
4AOB_A 0.26 0.24 0.30 7 1414 17 2 14 1 22
4ATO_G - -0.03 0.00 0.00 0 213 7 4 3 0 7
4ENB_A 0.45 0.40 0.55 6 461 5 1 4 0 9
4ENC_A 0.34 0.33 0.38 5 483 9 0 8 1 10
4FRG_B 0.54 0.50 0.60 12 1182 8 3 5 0 12
4JF2_A 0.72 0.67 0.80 16 1062 4 4 0 0 8
4JRC_A - 0.71 0.65 0.79 11 608 3 2 1 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.