CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold5 - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold5 & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold5 Carnac(seed)
MCC 0.547 > 0.212
Average MCC ± 95% Confidence Intervals 0.537 ± 0.168 > 0.068 ± 0.103
Sensitivity 0.545 > 0.045
Positive Predictive Value 0.560 < 1.000
Total TP 277 > 23
Total TN 39665 < 40137
Total FP 276 > 0
Total FP CONTRA 67 > 0
Total FP INCONS 151 > 0
Total FP COMP 58 > 0
Total FN 231 < 485
P-value 5.06544643719e-08

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Performance plots


  1. Comparison of performance of Vsfold5 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold5 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

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Performance of Vsfold5 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 277
Total TN 39665
Total FP 276
Total FP CONTRA 67
Total FP INCONS 151
Total FP COMP 58
Total FN 231
Total Scores
MCC 0.547
Average MCC ± 95% Confidence Intervals 0.537 ± 0.168
Sensitivity 0.545
Positive Predictive Value 0.560
Nr of predictions 20

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3GX2_A 0.61 0.57 0.67 16 1425 9 0 8 1 12
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3J3E_8 0.10 0.13 0.08 2 2718 31 10 12 9 13
3J3F_8 0.36 0.47 0.27 9 4728 38 13 11 14 10
3LA5_A -0.02 0.00 0.00 0 938 16 0 16 0 25
3NPB_A 0.62 0.54 0.71 20 2250 10 1 7 2 17
3O58_3 0.51 0.59 0.45 13 4735 28 11 5 12 9
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
3W3S_B 0.83 0.85 0.82 28 1955 7 2 4 1 5
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10
4FRN_A 0.15 0.14 0.17 4 1825 19 3 16 0 24
4JF2_A 0.96 1.00 0.92 24 1056 2 2 0 0 0

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 23
Total TN 40137
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 485
Total Scores
MCC 0.212
Average MCC ± 95% Confidence Intervals 0.068 ± 0.103
Sensitivity 0.045
Positive Predictive Value 1.000
Nr of predictions 20

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.22 1.00 4 524 0 0 0 0 14
3A3A_A 0.00 0.00 0.00 0 1500 0 0 0 0 30
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24
4FRN_A 0.00 0.00 0.00 0 1848 0 0 0 0 28
4JF2_A 0.89 0.79 1.00 19 1063 0 0 0 0 5

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.