CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold5 - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold5 & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold5 PPfold(seed)
MCC 0.519 > 0.220
Average MCC ± 95% Confidence Intervals 0.526 ± 0.202 > 0.102 ± 0.124
Sensitivity 0.541 > 0.072
Positive Predictive Value 0.510 < 0.686
Total TP 180 > 24
Total TN 25306 < 25624
Total FP 215 > 56
Total FP CONTRA 58 > 1
Total FP INCONS 115 > 10
Total FP COMP 42 < 45
Total FN 153 < 309
P-value 2.54914456376e-08

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Performance plots


  1. Comparison of performance of Vsfold5 and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold5 and PPfold(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold5 and PPfold(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold5 and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold5 and PPfold(seed)).

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Performance of Vsfold5 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 180
Total TN 25306
Total FP 215
Total FP CONTRA 58
Total FP INCONS 115
Total FP COMP 42
Total FN 153
Total Scores
MCC 0.519
Average MCC ± 95% Confidence Intervals 0.526 ± 0.202
Sensitivity 0.541
Positive Predictive Value 0.510
Nr of predictions 15

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
3J20_0 0.76 0.76 0.76 16 1198 6 3 2 1 5
3J3D_C 0.63 0.68 0.59 13 946 9 3 6 0 6
3J3E_8 0.10 0.13 0.08 2 2718 31 10 12 9 13
3J3F_8 0.36 0.47 0.27 9 4728 38 13 11 14 10
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
3W3S_B 0.83 0.85 0.82 28 1955 7 2 4 1 5
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10
4FRN_A 0.15 0.14 0.17 4 1825 19 3 16 0 24
4JF2_A 0.96 1.00 0.92 24 1056 2 2 0 0 0

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 24
Total TN 25624
Total FP 56
Total FP CONTRA 1
Total FP INCONS 10
Total FP COMP 45
Total FN 309
Total Scores
MCC 0.220
Average MCC ± 95% Confidence Intervals 0.102 ± 0.124
Sensitivity 0.072
Positive Predictive Value 0.686
Nr of predictions 15

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.49 0.33 0.75 6 520 2 0 2 0 12
3J20_0 0.00 0.00 0.00 0 1219 0 0 0 0 21
3J3D_C 0.00 0.00 0.00 0 968 0 0 0 0 19
3J3E_8 0.00 0.00 0.00 0 2742 6 0 0 6 15
3J3F_8 0.19 0.11 0.33 2 4755 24 0 4 20 17
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
4A1C_2 0.10 0.05 0.20 1 4511 23 0 4 19 19
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24
4FRN_A 0.00 0.00 0.00 0 1848 0 0 0 0 28
4JF2_A 0.76 0.63 0.94 15 1066 1 1 0 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.