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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Afold TurboFold(seed)
MCC 0.414 > 0.326
Average MCC ± 95% Confidence Intervals 0.471 ± 0.365 > 0.353 ± 0.433
Sensitivity 0.374 > 0.281
Positive Predictive Value 0.464 > 0.386
Total TP 52 > 39
Total TN 24198 < 24209
Total FP 83 > 80
Total FP CONTRA 8 > 7
Total FP INCONS 52 < 55
Total FP COMP 23 > 18
Total FN 87 < 100
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 52
Total TN 24198
Total FP 83
Total FP CONTRA 8
Total FP INCONS 52
Total FP COMP 23
Total FN 87
Total Scores
MCC 0.414
Average MCC ± 95% Confidence Intervals 0.471 ± 0.365
Sensitivity 0.374
Positive Predictive Value 0.464
Nr of predictions 5

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.61 0.55 0.69 11 1524 6 0 5 1 9
3J3E_8 0.17 0.15 0.19 5 7477 31 2 19 10 28
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
4A1C_2 0.14 0.15 0.14 5 11745 43 5 26 12 28
4ENB_A 0.67 0.58 0.79 11 1261 3 1 2 0 8

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 39
Total TN 24209
Total FP 80
Total FP CONTRA 7
Total FP INCONS 55
Total FP COMP 18
Total FN 100
Total Scores
MCC 0.326
Average MCC ± 95% Confidence Intervals 0.353 ± 0.433
Sensitivity 0.281
Positive Predictive Value 0.386
Nr of predictions 5

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3J3E_8 0.17 0.15 0.21 5 7479 28 2 17 9 28
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
4A1C_2 0.15 0.15 0.15 5 11748 37 3 25 9 28
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.