CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Alterna - scored higher in this pairwise comparison

  4. Performance of CRWrnafold - scored lower in this pairwise comparison

  5. Compile and download dataset for Alterna & CRWrnafold [.zip] - may take several seconds...


Overview

Metric Alterna CRWrnafold
MCC 0.457 > 0.450
Average MCC ± 95% Confidence Intervals 0.381 ± 0.219 > 0.341 ± 0.329
Sensitivity 0.404 > 0.391
Positive Predictive Value 0.529 < 0.530
Total TP 63 > 61
Total TN 13933 < 13937
Total FP 58 > 56
Total FP CONTRA 7 > 6
Total FP INCONS 49 > 48
Total FP COMP 2 = 2
Total FN 93 < 95
P-value 0.0

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Performance plots


  1. Comparison of performance of Alterna and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Alterna and CRWrnafold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Alterna and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Alterna and CRWrnafold).

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Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 63
Total TN 13933
Total FP 58
Total FP CONTRA 7
Total FP INCONS 49
Total FP COMP 2
Total FN 93
Total Scores
MCC 0.457
Average MCC ± 95% Confidence Intervals 0.381 ± 0.219
Sensitivity 0.404
Positive Predictive Value 0.529
Nr of predictions 7

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.46 0.40 0.53 8 1525 7 0 7 0 12
3AMU_B 0.64 0.59 0.70 16 2980 9 0 7 2 11
3J0L_a - 0.23 0.19 0.30 3 1118 7 1 6 0 13
3J0L_7 - 0.26 0.24 0.31 4 1212 9 0 9 0 13
3J0L_g - -0.01 0.00 0.00 0 456 9 4 5 0 4
3J16_L 0.63 0.53 0.76 16 2754 5 1 4 0 14
3SD1_A 0.46 0.38 0.57 16 3888 12 1 11 0 26

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 61
Total TN 13937
Total FP 56
Total FP CONTRA 6
Total FP INCONS 48
Total FP COMP 2
Total FN 95
Total Scores
MCC 0.450
Average MCC ± 95% Confidence Intervals 0.341 ± 0.329
Sensitivity 0.391
Positive Predictive Value 0.530
Nr of predictions 7

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3AMU_B 0.67 0.59 0.76 16 2982 7 0 5 2 11
3J0L_a - 0.39 0.31 0.50 5 1118 5 1 4 0 11
3J0L_7 - -0.01 0.00 0.00 0 1212 13 0 13 0 17
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J16_L 0.84 0.70 1.00 21 2754 0 0 0 0 9
3SD1_A 0.52 0.45 0.61 19 3885 12 2 10 0 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.