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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Alterna - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Alterna & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Alterna TurboFold(seed)
MCC 0.540 > 0.514
Average MCC ± 95% Confidence Intervals 0.536 ± 0.333 > 0.448 ± 1.011
Sensitivity 0.448 > 0.417
Positive Predictive Value 0.662 > 0.645
Total TP 43 > 40
Total TN 7602 < 7605
Total FP 22 = 22
Total FP CONTRA 2 < 3
Total FP INCONS 20 > 19
Total FP COMP 0 = 0
Total FN 53 < 56
P-value 0.0

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Performance plots


  1. Comparison of performance of Alterna and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Alterna and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Alterna and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Alterna and TurboFold(seed)).

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Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 43
Total TN 7602
Total FP 22
Total FP CONTRA 2
Total FP INCONS 20
Total FP COMP 0
Total FN 53
Total Scores
MCC 0.540
Average MCC ± 95% Confidence Intervals 0.536 ± 0.333
Sensitivity 0.448
Positive Predictive Value 0.662
Nr of predictions 3

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.46 0.40 0.53 8 1525 7 0 7 0 12
3RKF_A 0.69 0.56 0.86 19 2189 3 1 2 0 15
3SD1_A 0.46 0.38 0.57 16 3888 12 1 11 0 26

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 40
Total TN 7605
Total FP 22
Total FP CONTRA 3
Total FP INCONS 19
Total FP COMP 0
Total FN 56
Total Scores
MCC 0.514
Average MCC ± 95% Confidence Intervals 0.448 ± 1.011
Sensitivity 0.417
Positive Predictive Value 0.645
Nr of predictions 3

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.59 0.48 0.74 20 3889 7 1 6 0 22

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.