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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric CMfinder(20) TurboFold(seed)
MCC 0.296 > 0.290
Average MCC ± 95% Confidence Intervals 0.272 ± 2.210 < 0.281 ± 1.353
Sensitivity 0.203 < 0.261
Positive Predictive Value 0.438 > 0.327
Total TP 14 < 18
Total TN 19717 > 19694
Total FP 18 < 60
Total FP CONTRA 2 < 4
Total FP INCONS 16 < 33
Total FP COMP 0 < 23
Total FN 55 > 51
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and TurboFold(seed)).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 14
Total TN 19717
Total FP 18
Total FP CONTRA 2
Total FP INCONS 16
Total FP COMP 0
Total FN 55
Total Scores
MCC 0.296
Average MCC ± 95% Confidence Intervals 0.272 ± 2.210
Sensitivity 0.203
Positive Predictive Value 0.438
Nr of predictions 2

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.10 0.06 0.17 2 7491 10 1 9 0 31
3J3F_8 0.45 0.33 0.60 12 12226 8 1 7 0 24

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 18
Total TN 19694
Total FP 60
Total FP CONTRA 4
Total FP INCONS 33
Total FP COMP 23
Total FN 51
Total Scores
MCC 0.290
Average MCC ± 95% Confidence Intervals 0.281 ± 1.353
Sensitivity 0.261
Positive Predictive Value 0.327
Nr of predictions 2

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.17 0.15 0.21 5 7479 28 2 17 9 28
3J3F_8 0.39 0.36 0.42 13 12215 32 2 16 14 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.