CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(20) Carnac(seed)
MCC 0.572 > 0.110
Average MCC ± 95% Confidence Intervals 0.509 ± 0.112 > 0.043 ± 0.090
Sensitivity 0.355 > 0.012
Positive Predictive Value 0.927 < 1.000
Total TP 290 > 10
Total TN 143787 < 144090
Total FP 37 > 0
Total FP CONTRA 3 > 0
Total FP INCONS 20 > 0
Total FP COMP 14 > 0
Total FN 527 < 807
P-value 5.19332990918e-08

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Performance plots


  1. Comparison of performance of Carnac(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Carnac(seed)).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 290
Total TN 143787
Total FP 37
Total FP CONTRA 3
Total FP INCONS 20
Total FP COMP 14
Total FN 527
Total Scores
MCC 0.572
Average MCC ± 95% Confidence Intervals 0.509 ± 0.112
Sensitivity 0.355
Positive Predictive Value 0.927
Nr of predictions 22

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.73 0.55 1.00 6 400 0 0 0 0 5
3GX2_A 0.57 0.33 1.00 13 4358 0 0 0 0 27
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IZF_C 0.73 0.56 0.97 30 6872 1 0 1 0 24
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3F_8 0.50 0.25 1.00 9 12237 0 0 0 0 27
3JYX_4 0.46 0.21 1.00 7 12239 2 0 0 2 26
3JYX_3 0.64 0.56 0.75 15 6308 10 1 4 5 12
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.44 0.20 1.00 9 7012 2 0 0 2 37
3O58_2 0.83 0.71 0.96 27 7232 2 0 1 1 11
3O58_3 0.51 0.26 1.00 9 12394 0 0 0 0 26
3PDR_A 0.62 0.40 0.97 29 12850 3 0 1 2 43
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
3ZEX_C 0.31 0.13 0.70 7 14186 3 1 2 0 45
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4A1C_2 0.33 0.15 0.71 5 11774 3 0 2 1 28
4AOB_A 0.49 0.33 0.74 14 4352 6 1 4 1 28
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.43 0.19 1.00 6 3480 0 0 0 0 26

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 10
Total TN 144090
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 807
Total Scores
MCC 0.110
Average MCC ± 95% Confidence Intervals 0.043 ± 0.090
Sensitivity 0.012
Positive Predictive Value 1.000
Nr of predictions 22

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.