CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(seed) - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(seed) & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(seed) PPfold(seed)
MCC 0.202 > 0.194
Average MCC ± 95% Confidence Intervals 0.077 ± 0.116 < 0.106 ± 0.111
Sensitivity 0.041 < 0.055
Positive Predictive Value 1.000 > 0.689
Total TP 23 < 31
Total TN 87908 > 87886
Total FP 0 < 75
Total FP CONTRA 0 = 0
Total FP INCONS 0 < 14
Total FP COMP 0 < 61
Total FN 538 > 530
P-value 0.00321313388056

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Performance plots


  1. Comparison of performance of Carnac(seed) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(seed) and PPfold(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(seed) and PPfold(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(seed) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(seed) and PPfold(seed)).

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Performance of Carnac(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 23
Total TN 87908
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 538
Total Scores
MCC 0.202
Average MCC ± 95% Confidence Intervals 0.077 ± 0.116
Sensitivity 0.041
Positive Predictive Value 1.000
Nr of predictions 16

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3W1K_J 0.00 0.00 0.00 0 4186 0 0 0 0 38
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36
4JF2_A 0.78 0.61 1.00 19 2831 0 0 0 0 12

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 31
Total TN 87886
Total FP 75
Total FP CONTRA 0
Total FP INCONS 14
Total FP COMP 61
Total FN 530
Total Scores
MCC 0.194
Average MCC ± 95% Confidence Intervals 0.106 ± 0.111
Sensitivity 0.055
Positive Predictive Value 0.689
Nr of predictions 16

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.30 0.75 6 1532 2 0 2 0 14
3J3E_8 0.00 0.00 0.00 0 7503 6 0 0 6 33
3J3F_8 0.23 0.11 0.50 4 12238 22 0 4 18 32
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3W1K_J 0.00 0.00 0.00 0 4186 0 0 0 0 38
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
3ZEX_C 0.20 0.08 0.50 4 14188 22 0 4 18 48
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.08 0.03 0.20 1 11776 23 0 4 19 32
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36
4JF2_A 0.72 0.52 1.00 16 2834 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.