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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) Multilign(seed)
MCC 0.569 > 0.497
Average MCC ± 95% Confidence Intervals 0.513 ± 0.404 > 0.489 ± 0.300
Sensitivity 0.369 = 0.369
Positive Predictive Value 0.882 > 0.676
Total TP 75 = 75
Total TN 32112 > 32086
Total FP 11 < 37
Total FP CONTRA 1 < 9
Total FP INCONS 9 < 27
Total FP COMP 1 = 1
Total FN 128 = 128
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 75
Total TN 32112
Total FP 11
Total FP CONTRA 1
Total FP INCONS 9
Total FP COMP 1
Total FN 128
Total Scores
MCC 0.569
Average MCC ± 95% Confidence Intervals 0.513 ± 0.404
Sensitivity 0.369
Positive Predictive Value 0.882
Nr of predictions 5

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.00 0.00 0.00 0 7499 4 0 4 0 33
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.71 0.52 0.96 22 3893 1 0 1 0 20
3ZEX_C 0.38 0.21 0.69 11 14180 5 1 4 0 41
4AOB_A 0.75 0.57 1.00 24 4347 1 0 0 1 18

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 32086
Total FP 37
Total FP CONTRA 9
Total FP INCONS 27
Total FP COMP 1
Total FN 128
Total Scores
MCC 0.497
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300
Sensitivity 0.369
Positive Predictive Value 0.676
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.