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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric Cylofold CMfinder(20)
MCC 0.596 > 0.530
Average MCC ± 95% Confidence Intervals 0.599 ± 0.188 > 0.538 ± 0.162
Sensitivity 0.503 > 0.369
Positive Predictive Value 0.712 < 0.767
Total TP 94 > 69
Total TN 24103 < 24145
Total FP 43 > 26
Total FP CONTRA 3 > 1
Total FP INCONS 35 > 20
Total FP COMP 5 = 5
Total FN 93 < 118
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and CMfinder(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and CMfinder(20)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 94
Total TN 24103
Total FP 43
Total FP CONTRA 3
Total FP INCONS 35
Total FP COMP 5
Total FN 93
Total Scores
MCC 0.596
Average MCC ± 95% Confidence Intervals 0.599 ± 0.188
Sensitivity 0.503
Positive Predictive Value 0.712
Nr of predictions 5

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3ZEX_D 0.58 0.49 0.69 24 6986 11 0 11 0 25
3ZND_W 0.40 0.39 0.41 9 2981 15 2 11 2 14
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 69
Total TN 24145
Total FP 26
Total FP CONTRA 1
Total FP INCONS 20
Total FP COMP 5
Total FN 118
Total Scores
MCC 0.530
Average MCC ± 95% Confidence Intervals 0.538 ± 0.162
Sensitivity 0.369
Positive Predictive Value 0.767
Nr of predictions 5

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.75 0.57 1.00 17 2833 1 0 0 1 13
3J2L_3 0.45 0.32 0.63 17 7848 11 1 9 1 36
3ZEX_D 0.58 0.39 0.86 19 6999 3 0 3 0 30
3ZND_W 0.45 0.39 0.53 9 2986 11 0 8 3 14
4FRG_B 0.47 0.22 1.00 7 3479 0 0 0 0 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.