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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric Cylofold Mastr(seed)
MCC 0.618 > 0.000
Average MCC ± 95% Confidence Intervals 0.635 ± 0.080 > 0.000 ± 0.000
Sensitivity 0.519 > 0.000
Positive Predictive Value 0.741 > 0.000
Total TP 430 > 0
Total TN 106330 < 106910
Total FP 172 > 0
Total FP CONTRA 19 > 0
Total FP INCONS 131 > 0
Total FP COMP 22 > 0
Total FN 398 < 828
P-value 5.10776592382e-08

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Performance plots


  1. Comparison of performance of Cylofold and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Cylofold and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and Mastr(seed)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 430
Total TN 106330
Total FP 172
Total FP CONTRA 19
Total FP INCONS 131
Total FP COMP 22
Total FN 398
Total Scores
MCC 0.618
Average MCC ± 95% Confidence Intervals 0.635 ± 0.080
Sensitivity 0.519
Positive Predictive Value 0.741
Nr of predictions 24

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
2XQD_Y 0.81 0.78 0.84 21 2825 4 4 0 0 6
3AKZ_H 0.66 0.57 0.76 16 2680 6 0 5 1 12
3AMU_B 0.67 0.59 0.76 16 2982 7 0 5 2 11
3IZF_C 0.68 0.56 0.83 30 6867 6 0 6 0 24
3J16_L 0.75 0.57 1.00 17 2758 0 0 0 0 13
3J20_1 0.69 0.70 0.70 16 2903 7 2 5 0 7
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3O58_2 0.80 0.68 0.93 26 7232 3 0 2 1 12
3O58_3 0.36 0.34 0.38 12 12371 29 5 15 9 23
3PDR_A 0.72 0.54 0.95 39 12839 4 0 2 2 33
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.62 0.50 0.78 21 3889 6 0 6 0 21
3UZL_B 0.45 0.38 0.54 14 3544 12 1 11 0 23
3W3S_B 0.44 0.38 0.52 15 4724 15 0 14 1 25
3ZEX_D 0.58 0.49 0.69 24 6986 11 0 11 0 25
3ZND_W 0.40 0.39 0.41 9 2981 15 2 11 2 14
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11
4FRN_A 0.20 0.14 0.31 5 5135 11 2 9 0 31

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 106910
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 828
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 24

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KX8_A 0.00 0.00 0.00 0 861 0 0 0 0 18
2LC8_A 0.00 0.00 0.00 0 1540 0 0 0 0 20
2XQD_Y 0.00 0.00 0.00 0 2850 0 0 0 0 27
3AKZ_H 0.00 0.00 0.00 0 2701 0 0 0 0 28
3AMU_B 0.00 0.00 0.00 0 3003 0 0 0 0 27
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3J16_L 0.00 0.00 0.00 0 2775 0 0 0 0 30
3J20_1 0.00 0.00 0.00 0 2926 0 0 0 0 23
3J20_0 0.00 0.00 0.00 0 2850 0 0 0 0 30
3J2L_3 0.00 0.00 0.00 0 7875 0 0 0 0 53
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3UZL_B 0.00 0.00 0.00 0 3570 0 0 0 0 37
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
3ZEX_D 0.00 0.00 0.00 0 7021 0 0 0 0 49
3ZND_W 0.00 0.00 0.00 0 3003 0 0 0 0 23
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.