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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(20) Multilign(seed)
MCC 0.502 > 0.497
Average MCC ± 95% Confidence Intervals 0.487 ± 0.309 < 0.489 ± 0.300
Sensitivity 0.384 > 0.369
Positive Predictive Value 0.661 < 0.676
Total TP 78 > 75
Total TN 32079 < 32086
Total FP 46 > 37
Total FP CONTRA 6 < 9
Total FP INCONS 34 > 27
Total FP COMP 6 > 1
Total FN 125 < 128
P-value 0.0

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Performance plots


  1. Comparison of performance of MXScarna(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Multilign(seed)).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 78
Total TN 32079
Total FP 46
Total FP CONTRA 6
Total FP INCONS 34
Total FP COMP 6
Total FN 125
Total Scores
MCC 0.502
Average MCC ± 95% Confidence Intervals 0.487 ± 0.309
Sensitivity 0.384
Positive Predictive Value 0.661
Nr of predictions 5

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.14 0.09 0.23 3 7490 15 2 8 5 30
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.63 0.55 0.74 23 3885 8 2 6 0 19
3ZEX_C 0.31 0.21 0.46 11 14172 13 2 11 0 41
4AOB_A 0.62 0.55 0.72 23 4339 10 0 9 1 19

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 32086
Total FP 37
Total FP CONTRA 9
Total FP INCONS 27
Total FP COMP 1
Total FN 128
Total Scores
MCC 0.497
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300
Sensitivity 0.369
Positive Predictive Value 0.676
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.