CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Mastr(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Mastr(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Mastr(20) Carnac(seed)
MCC 0.471 > 0.110
Average MCC ± 95% Confidence Intervals 0.389 ± 0.149 > 0.043 ± 0.090
Sensitivity 0.293 > 0.012
Positive Predictive Value 0.764 < 1.000
Total TP 239 > 10
Total TN 143787 < 144090
Total FP 94 > 0
Total FP CONTRA 8 > 0
Total FP INCONS 66 > 0
Total FP COMP 20 > 0
Total FN 578 < 807
P-value 4.89920829651e-08

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Performance plots


  1. Comparison of performance of Mastr(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Mastr(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(20) and Carnac(seed)).

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Performance of Mastr(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 239
Total TN 143787
Total FP 94
Total FP CONTRA 8
Total FP INCONS 66
Total FP COMP 20
Total FN 578
Total Scores
MCC 0.471
Average MCC ± 95% Confidence Intervals 0.389 ± 0.149
Sensitivity 0.293
Positive Predictive Value 0.764
Nr of predictions 22

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
3GX2_A 0.39 0.28 0.55 11 4351 10 0 9 1 29
3IVN_B 0.78 0.65 0.95 20 2325 1 1 0 0 11
3IZF_C 0.73 0.63 0.85 34 6863 7 1 5 1 20
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.56 0.56 0.58 15 6302 23 1 10 12 12
3LA5_A 0.76 0.59 1.00 20 2465 0 0 0 0 14
3NPB_A 0.30 0.24 0.39 11 6993 18 1 16 1 35
3O58_2 0.76 0.76 0.76 29 7222 12 3 6 3 9
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.70 0.50 1.00 17 2194 0 0 0 0 17
3SD1_A 0.61 0.50 0.75 21 3888 7 1 6 0 21
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_3 0.70 0.59 0.84 32 7102 7 0 6 1 22
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.39 0.26 0.58 11 4352 9 0 8 1 31
4ENB_A 0.39 0.16 1.00 3 1272 0 0 0 0 16
4ENC_A 0.51 0.26 1.00 5 1321 0 0 0 0 14
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 10
Total TN 144090
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 807
Total Scores
MCC 0.110
Average MCC ± 95% Confidence Intervals 0.043 ± 0.090
Sensitivity 0.012
Positive Predictive Value 1.000
Nr of predictions 22

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.