CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Mastr(20) - scored higher in this pairwise comparison

  4. Performance of RNASLOpt - scored lower in this pairwise comparison

  5. Compile and download dataset for Mastr(20) & RNASLOpt [.zip] - may take several seconds...


Overview

Metric Mastr(20) RNASLOpt
MCC 0.465 > 0.463
Average MCC ± 95% Confidence Intervals 0.367 ± 0.163 < 0.490 ± 0.131
Sensitivity 0.313 < 0.383
Positive Predictive Value 0.698 > 0.567
Total TP 215 < 263
Total TN 110887 > 110731
Total FP 100 < 248
Total FP CONTRA 5 < 21
Total FP INCONS 88 < 180
Total FP COMP 7 < 47
Total FN 472 > 424
P-value 0.371318546591

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Performance plots


  1. Comparison of performance of Mastr(20) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(20) and RNASLOpt).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Mastr(20) and RNASLOpt).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(20) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(20) and RNASLOpt).

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Performance of Mastr(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 215
Total TN 110887
Total FP 100
Total FP CONTRA 5
Total FP INCONS 88
Total FP COMP 7
Total FN 472
Total Scores
MCC 0.465
Average MCC ± 95% Confidence Intervals 0.367 ± 0.163
Sensitivity 0.313
Positive Predictive Value 0.698
Nr of predictions 18

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.25 0.22 0.29 5 2909 12 0 12 0 18
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2L_3 0.34 0.25 0.48 13 7848 16 1 13 2 40
3J3D_C 0.82 0.71 0.95 20 2754 1 0 1 0 8
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3E_7 0.66 0.57 0.76 31 7099 10 1 9 0 23
3J3F_7 0.72 0.64 0.82 32 7221 8 0 7 1 18
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3J3V_B 0.19 0.12 0.30 7 6998 16 0 16 0 50
3ZEX_D 0.80 0.71 0.90 35 6982 4 0 4 0 14
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
3ZND_W -0.01 0.00 0.00 0 2988 16 3 12 1 23
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4A1C_3 0.70 0.59 0.84 32 7102 7 0 6 1 22
4AOB_A 0.39 0.26 0.58 11 4352 9 0 8 1 31
4ENB_A 0.39 0.16 1.00 3 1272 0 0 0 0 16
4ENC_A 0.51 0.26 1.00 5 1321 0 0 0 0 14
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 263
Total TN 110731
Total FP 248
Total FP CONTRA 21
Total FP INCONS 180
Total FP COMP 47
Total FN 424
Total Scores
MCC 0.463
Average MCC ± 95% Confidence Intervals 0.490 ± 0.131
Sensitivity 0.383
Positive Predictive Value 0.567
Nr of predictions 18

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3J3D_C 0.82 0.71 0.95 20 2754 1 0 1 0 8
3J3E_8 0.00 0.00 0.00 0 7483 30 1 19 10 33
3J3E_7 0.48 0.35 0.66 19 7111 10 0 10 0 35
3J3F_7 0.18 0.16 0.22 8 7224 28 1 27 0 42
3J3F_8 0.34 0.33 0.35 12 12212 35 3 19 13 24
3J3V_B 0.46 0.33 0.63 19 6991 11 0 11 0 38
3ZEX_D 0.76 0.59 0.97 29 6991 1 0 1 0 20
3ZEX_C 0.26 0.21 0.33 11 14163 35 2 20 13 41
3ZND_W 0.21 0.22 0.22 5 2980 20 1 17 2 18
4A1C_2 0.23 0.24 0.22 8 11744 35 8 21 6 25
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4AOB_A 0.26 0.19 0.38 8 4350 13 2 11 0 34
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.