CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Carnac(20)
MCC 0.497 > 0.491
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300 > 0.432 ± 0.364
Sensitivity 0.369 > 0.281
Positive Predictive Value 0.676 < 0.864
Total TP 75 > 57
Total TN 32086 < 32131
Total FP 37 > 10
Total FP CONTRA 9 > 2
Total FP INCONS 27 > 7
Total FP COMP 1 = 1
Total FN 128 < 146
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 32086
Total FP 37
Total FP CONTRA 9
Total FP INCONS 27
Total FP COMP 1
Total FN 128
Total Scores
MCC 0.497
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300
Sensitivity 0.369
Positive Predictive Value 0.676
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 57
Total TN 32131
Total FP 10
Total FP CONTRA 2
Total FP INCONS 7
Total FP COMP 1
Total FN 146
Total Scores
MCC 0.491
Average MCC ± 95% Confidence Intervals 0.432 ± 0.364
Sensitivity 0.281
Positive Predictive Value 0.864
Nr of predictions 5

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
3ZEX_C 0.31 0.13 0.70 7 14186 3 1 2 0 45
4AOB_A 0.49 0.33 0.74 14 4352 6 1 4 1 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.