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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Cylofold [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Cylofold
MCC 0.554 > 0.492
Average MCC ± 95% Confidence Intervals 0.498 ± 0.340 > 0.498 ± 0.215
Sensitivity 0.435 > 0.388
Positive Predictive Value 0.715 > 0.634
Total TP 93 > 83
Total TN 21812 > 21811
Total FP 39 < 50
Total FP CONTRA 3 = 3
Total FP INCONS 34 < 45
Total FP COMP 2 = 2
Total FN 121 < 131
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Cylofold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Cylofold).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 93
Total TN 21812
Total FP 39
Total FP CONTRA 3
Total FP INCONS 34
Total FP COMP 2
Total FN 121
Total Scores
MCC 0.554
Average MCC ± 95% Confidence Intervals 0.498 ± 0.340
Sensitivity 0.435
Positive Predictive Value 0.715
Nr of predictions 6

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3W3S_B 0.84 0.73 0.97 29 4723 2 0 1 1 11
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23
4FRN_A 0.24 0.17 0.35 6 5134 11 1 10 0 30

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 83
Total TN 21811
Total FP 50
Total FP CONTRA 3
Total FP INCONS 45
Total FP COMP 2
Total FN 131
Total Scores
MCC 0.492
Average MCC ± 95% Confidence Intervals 0.498 ± 0.215
Sensitivity 0.388
Positive Predictive Value 0.634
Nr of predictions 6

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.62 0.50 0.78 21 3889 6 0 6 0 21
3W3S_B 0.44 0.38 0.52 15 4724 15 0 14 1 25
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4FRN_A 0.20 0.14 0.31 5 5135 11 2 9 0 31

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.