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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Multilign(20)
MCC 0.529 > 0.465
Average MCC ± 95% Confidence Intervals 0.513 ± 0.433 > 0.455 ± 0.520
Sensitivity 0.404 > 0.377
Positive Predictive Value 0.701 > 0.582
Total TP 61 > 57
Total TN 17914 > 17903
Total FP 27 < 42
Total FP CONTRA 6 < 8
Total FP INCONS 20 < 33
Total FP COMP 1 = 1
Total FN 90 < 94
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Multilign(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 61
Total TN 17914
Total FP 27
Total FP CONTRA 6
Total FP INCONS 20
Total FP COMP 1
Total FN 90
Total Scores
MCC 0.529
Average MCC ± 95% Confidence Intervals 0.513 ± 0.433
Sensitivity 0.404
Positive Predictive Value 0.701
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 57
Total TN 17903
Total FP 42
Total FP CONTRA 8
Total FP INCONS 33
Total FP COMP 1
Total FN 94
Total Scores
MCC 0.465
Average MCC ± 95% Confidence Intervals 0.455 ± 0.520
Sensitivity 0.377
Positive Predictive Value 0.582
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.00 0.00 0.00 0 7481 22 6 16 0 33
3RKF_A 0.77 0.62 0.95 21 2189 1 0 1 0 13
3SD1_A 0.57 0.48 0.69 20 3887 9 1 8 0 22
4AOB_A 0.49 0.38 0.64 16 4346 10 1 8 1 26

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.