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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Multilign(seed) NanoFolder
MCC 0.541 > 0.278
Average MCC ± 95% Confidence Intervals 0.469 ± 0.480 > 0.304 ± 0.279
Sensitivity 0.422 > 0.283
Positive Predictive Value 0.700 > 0.285
Total TP 70 > 47
Total TN 20917 > 20852
Total FP 32 < 130
Total FP CONTRA 6 < 13
Total FP INCONS 24 < 105
Total FP COMP 2 < 12
Total FN 96 < 119
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and NanoFolder).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 70
Total TN 20917
Total FP 32
Total FP CONTRA 6
Total FP INCONS 24
Total FP COMP 2
Total FN 96
Total Scores
MCC 0.541
Average MCC ± 95% Confidence Intervals 0.469 ± 0.480
Sensitivity 0.422
Positive Predictive Value 0.700
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3W3S_B 0.84 0.73 0.97 29 4723 2 0 1 1 11
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23
4JF2_A 0.78 0.61 1.00 19 2831 0 0 0 0 12

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 47
Total TN 20852
Total FP 130
Total FP CONTRA 13
Total FP INCONS 105
Total FP COMP 12
Total FN 119
Total Scores
MCC 0.278
Average MCC ± 95% Confidence Intervals 0.304 ± 0.279
Sensitivity 0.283
Positive Predictive Value 0.285
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.52 0.55 0.50 11 1518 11 0 11 0 9
3J3E_8 0.00 0.00 0.00 0 7466 47 6 31 10 33
3W3S_B 0.17 0.18 0.18 7 4713 34 1 32 1 33
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30
4JF2_A 0.51 0.55 0.49 17 2815 18 5 13 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.