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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RDfolder [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RDfolder
MCC 0.610 > 0.353
Average MCC ± 95% Confidence Intervals 0.550 ± 0.414 > 0.334 ± 0.346
Sensitivity 0.489 > 0.264
Positive Predictive Value 0.770 > 0.485
Total TP 87 > 47
Total TN 16678 < 16694
Total FP 28 < 51
Total FP CONTRA 2 < 4
Total FP INCONS 24 < 46
Total FP COMP 2 > 1
Total FN 91 < 131
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RDfolder).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 87
Total TN 16678
Total FP 28
Total FP CONTRA 2
Total FP INCONS 24
Total FP COMP 2
Total FN 91
Total Scores
MCC 0.610
Average MCC ± 95% Confidence Intervals 0.550 ± 0.414
Sensitivity 0.489
Positive Predictive Value 0.770
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3W3S_B 0.84 0.73 0.97 29 4723 2 0 1 1 11
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 47
Total TN 16694
Total FP 51
Total FP CONTRA 4
Total FP INCONS 46
Total FP COMP 1
Total FN 131
Total Scores
MCC 0.353
Average MCC ± 95% Confidence Intervals 0.334 ± 0.346
Sensitivity 0.264
Positive Predictive Value 0.485
Nr of predictions 5

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1526 14 2 12 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.30 0.17 0.54 7 3903 6 0 6 0 35
3W3S_B 0.27 0.23 0.33 9 4726 18 1 17 0 31
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.