CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RNASampler(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RNASampler(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RNASampler(20)
MCC 0.497 > 0.480
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300 > 0.483 ± 0.340
Sensitivity 0.369 > 0.345
Positive Predictive Value 0.676 > 0.673
Total TP 75 > 70
Total TN 32086 < 32093
Total FP 37 < 46
Total FP CONTRA 9 > 3
Total FP INCONS 27 < 31
Total FP COMP 1 < 12
Total FN 128 < 133
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RNASampler(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RNASampler(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 32086
Total FP 37
Total FP CONTRA 9
Total FP INCONS 27
Total FP COMP 1
Total FN 128
Total Scores
MCC 0.497
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300
Sensitivity 0.369
Positive Predictive Value 0.676
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 70
Total TN 32093
Total FP 46
Total FP CONTRA 3
Total FP INCONS 31
Total FP COMP 12
Total FN 133
Total Scores
MCC 0.480
Average MCC ± 95% Confidence Intervals 0.483 ± 0.340
Sensitivity 0.345
Positive Predictive Value 0.673
Nr of predictions 5

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.12 0.09 0.18 3 7486 21 2 12 7 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.67 0.48 0.95 20 3895 1 0 1 0 22
3ZEX_C 0.27 0.19 0.38 10 14170 20 1 15 4 42
4AOB_A 0.58 0.40 0.85 17 4351 4 0 3 1 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.