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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of TurboFold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & TurboFold(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) TurboFold(20)
MCC 0.497 > 0.489
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300 < 0.495 ± 0.278
Sensitivity 0.369 < 0.374
Positive Predictive Value 0.676 > 0.644
Total TP 75 < 76
Total TN 32086 > 32079
Total FP 37 < 55
Total FP CONTRA 9 > 6
Total FP INCONS 27 < 36
Total FP COMP 1 < 13
Total FN 128 > 127
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and TurboFold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and TurboFold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and TurboFold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and TurboFold(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 32086
Total FP 37
Total FP CONTRA 9
Total FP INCONS 27
Total FP COMP 1
Total FN 128
Total Scores
MCC 0.497
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300
Sensitivity 0.369
Positive Predictive Value 0.676
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of TurboFold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 76
Total TN 32079
Total FP 55
Total FP CONTRA 6
Total FP INCONS 36
Total FP COMP 13
Total FN 127
Total Scores
MCC 0.489
Average MCC ± 95% Confidence Intervals 0.495 ± 0.278
Sensitivity 0.374
Positive Predictive Value 0.644
Nr of predictions 5

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.17 0.15 0.21 5 7479 28 2 17 9 28
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.59 0.48 0.74 20 3889 7 1 6 0 22
3ZEX_C 0.39 0.27 0.56 14 14171 14 2 9 3 38
4AOB_A 0.56 0.40 0.77 17 4349 6 1 4 1 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.