CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Murlet(20) Carnac(seed)
MCC 0.553 > 0.110
Average MCC ± 95% Confidence Intervals 0.538 ± 0.087 > 0.043 ± 0.090
Sensitivity 0.404 > 0.012
Positive Predictive Value 0.762 < 1.000
Total TP 330 > 10
Total TN 143667 < 144090
Total FP 135 > 0
Total FP CONTRA 9 > 0
Total FP INCONS 94 > 0
Total FP COMP 32 > 0
Total FN 487 < 807
P-value 4.98172311752e-08

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Performance plots


  1. Comparison of performance of Murlet(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 330
Total TN 143667
Total FP 135
Total FP CONTRA 9
Total FP INCONS 94
Total FP COMP 32
Total FN 487
Total Scores
MCC 0.553
Average MCC ± 95% Confidence Intervals 0.538 ± 0.087
Sensitivity 0.404
Positive Predictive Value 0.762
Nr of predictions 22

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.67 0.45 1.00 5 401 0 0 0 0 6
3GX2_A 0.61 0.38 1.00 15 4356 1 0 0 1 25
3IVN_B 0.69 0.48 1.00 15 2331 0 0 0 0 16
3IZF_C 0.71 0.56 0.91 30 6870 4 0 3 1 24
3J3E_8 0.24 0.15 0.38 5 7490 13 1 7 5 28
3J3F_8 0.48 0.36 0.65 13 12226 10 0 7 3 23
3JYX_4 0.36 0.27 0.47 9 12227 15 0 10 5 24
3JYX_3 0.60 0.52 0.70 14 6308 11 0 6 5 13
3LA5_A 0.68 0.47 1.00 16 2469 0 0 0 0 18
3NPB_A 0.55 0.35 0.89 16 7003 2 1 1 0 30
3O58_2 0.89 0.82 0.97 31 7228 2 0 1 1 7
3O58_3 0.33 0.23 0.47 8 12386 12 2 7 3 27
3PDR_A 0.70 0.53 0.93 38 12839 3 0 3 0 34
3RKF_A 0.68 0.47 1.00 16 2195 0 0 0 0 18
3SD1_A 0.68 0.57 0.83 24 3887 5 1 4 0 18
3ZEX_C 0.34 0.23 0.50 12 14172 15 1 11 3 40
4A1C_3 0.59 0.41 0.85 22 7114 4 0 4 0 32
4A1C_2 0.17 0.15 0.20 5 11756 24 2 18 4 28
4AOB_A 0.72 0.55 0.96 23 4347 2 0 1 1 19
4ENB_A 0.46 0.21 1.00 4 1271 0 0 0 0 15
4ENC_A 0.51 0.26 1.00 5 1321 0 0 0 0 14
4FRG_B 0.17 0.13 0.25 4 3470 12 1 11 0 28

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 10
Total TN 144090
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 807
Total Scores
MCC 0.110
Average MCC ± 95% Confidence Intervals 0.043 ± 0.090
Sensitivity 0.012
Positive Predictive Value 1.000
Nr of predictions 22

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.